Antiandrogens

By definition, antiandrogens are substances that prevent or depress the action of male hormones in their target organs. Potential sites of action include go-nadotropin suppression, inhibition of androgen synthesis, and androgen receptor blockade. Compounds that affect each of these sites are available. Potential clinical uses of antiandrogens include suppression of androgen excess and treatment of androgen-dependent tumors.

Extreme clinical examples of androgen excess include central precocious puberty, the adrenogenital syndromes, and androgen-secreting adrenal, ovarian, or testicular tumors. Less severe problems include idio-pathic hirsutism, premenstrual syndrome, and severe cystic acne.

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