Angiotensin Receptor Antagonists

Angiotensin II can bind with high affinity to two distinct receptors, termed the angiotensin type 1 (ATI) and the angiotensin type 2 (AT2) receptor. These receptors belong to a superfamily of G protein-coupled receptors that contain seven transmembrane regions. The amino acid sequence of these receptors is highly conserved across species. The AT1 and AT2 receptors share only 34% homology, have distinct signal transduction pathways, and are not necessarily found on the same cell type or tissue. As previously discussed, most of the physiological effects of angiotensin II are mediated through effects at the AT1 receptor.

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