Amprenavir

Amprenavir (Agenerase) is administered twice daily, providing the patient with an advantage over other protease inhibitors that must be taken more frequently (e.g., indinavir, saquinavir). Common side effects of am-

prenavir include nausea, vomiting, diarrhea, and perioral paraesthesias. Rash occurs in approximately 20 to 30% of patients and can be mild or severe (StevensJohnson syndrome).

Amprenavir oral solution contains large amounts of the excipient propylene glycol and should not be given to children under age 4 because it can produce hyperosmo-lality, lactic acidosis, seizures, and/or respiratory depression. Pregnant women should not take amprenavir oral solution, as fetal toxicity may result. Amprenavir is a sul-fonamide and should be used with caution in patients with sulfonamide allergy. Amprenavir oral solution and capsules contain high levels of vitamin E; therefore, patients are advised not to take supplemental vitamin E. In addition to the drugs contraindicated for use with all protease inhibitors, amprenavir should not be given with pimozide or rifampin.

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