Amprenavir (Agenerase) is administered twice daily, providing the patient with an advantage over other protease inhibitors that must be taken more frequently (e.g., indinavir, saquinavir). Common side effects of am-

prenavir include nausea, vomiting, diarrhea, and perioral paraesthesias. Rash occurs in approximately 20 to 30% of patients and can be mild or severe (StevensJohnson syndrome).

Amprenavir oral solution contains large amounts of the excipient propylene glycol and should not be given to children under age 4 because it can produce hyperosmo-lality, lactic acidosis, seizures, and/or respiratory depression. Pregnant women should not take amprenavir oral solution, as fetal toxicity may result. Amprenavir is a sul-fonamide and should be used with caution in patients with sulfonamide allergy. Amprenavir oral solution and capsules contain high levels of vitamin E; therefore, patients are advised not to take supplemental vitamin E. In addition to the drugs contraindicated for use with all protease inhibitors, amprenavir should not be given with pimozide or rifampin.

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