Adverse Reactions to SERMs

Ovarian enlargement is the most common side effect of clomiphene use. The occurrence of multiple births following ovulation induction with clomiphene is 4 to 9%; 90% of these multiple births are twins. Since clo-miphene is teratogenic, therapy should be discontinued if there is a chance that conception has occurred. Rarely, irreversible ocular toxicities have been reported with clomiphene use.

Nausea, vomiting, and hot flashes may accompany tamoxifen administration. Tamoxifen may cause a transient flare of tumor growth and increased pain due to bone metastases. These reactions are thought to be due to an initial estrogenic action of this drug. Mild or tran sient depression of platelet counts often occurs in patients receiving tamoxifen. At very high doses, generally no longer used in cancer treatment, ocular toxicity has been reported. There is a slight risk of hepatocellular carcinoma in humans receiving long-term (5 years) tamoxifen therapy as well as a slightly (0.4%) elevated incidence of endometrial cancer.

Raloxifene and clomiphene use is associated with an increased frequency of vasomotor disturbances (hot flashes) and thromboembolism formation.

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook


Post a comment