Side effects are not a major problem, and they can be minimized by graduated dosage increases. They include lassitude, slight nausea, and mental disturbances (in cluding confusion, euphoria, and depression). The drowsiness is less pronounced than that produced by diazepam—an important therapeutic advantage. Hypotension has been noted, particularly following overdose. Elderly patients and patients with multiple sclerosis may require lower doses and may display increased sensitivity to the central side effects. Baclofen may increase the frequency of seizures in epileptics.
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