The principal adverse effect associated with throm-bolytic therapy is bleeding due to fibrinogenolysis or fibrinolysis at the site of vascular injury. Hypo-fibrinogenemia may occur and should be monitored with laboratory tests. At effective thrombolytic doses, the second- and third-generation agents cause less extensive fibrinogenolysis, but bleeding occurs with a similar incidence for all agents. Life-threatening intracra-nial bleeding may necessitate stoppage of therapy, administration of whole blood, platelets or fresh frozen plasma, protamine (if heparin is present), and an an-tifibrinolytic drug (discussed later).
Was this article helpful?
Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.