Adverse Effects

Most side effects associated with hydralazine administration are due to vasodilation and the reflex hemody-namic changes that occur in response to vasodilation. These side effects include headache, flushing, nasal congestion, tachycardia, and palpitations. More serious manifestations include myocardial ischemia and heart failure. These untoward effects of hydralazine are greatly attenuated when the drug is administered in conjunction with a p-blocker.

When administered chronically in high doses, hy-dralazine may produce a rheumatoidlike state that when fully developed, resembles disseminated lupus erythematosus.

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