Adverse Effects

All of the responses summarized in Table 14.2 can be produced by administration of ganglionic blocking agents. Many of these responses are undesirable effects that limit the therapeutic usefulness of these agents. Mild untoward responses include mydriasis, difficulty in vision accommodation, dry mouth, urinary hesitancy, constipation, diarrhea, abdominal discomfort, anorexia, and syncope. More serious but less frequent disturbances include marked hypotension, constipation, paralytic ileus, urinary retention, and anginal pain.


Trimethaphan camsylate (Arfonad) is an extremely short-acting agent whose major therapeutic use is in the production of controlled hypotension in certain surgical procedures and in the emergency treatment of hypertensive crisis. Continuous infusion may be employed to maintain its antihypertensive effect, especially in patients with an acute dissecting aortic aneurysm. Much of the decrease in blood pressure following trimethaphan administration is thought to be due to its direct vasodi-lating properties.

Trimethaphan can produce prolonged neuromuscular blockade in some patients, and therefore, it should be used with caution as a hypotensive agent during surgery. It also has been reported to potentiate the neuromuscular blocking action of tubocurarine, and because of its histamine-releasing properties, trimethaphan should be used with caution in patients with allergies.

Constipation Prescription

Constipation Prescription

Did you ever think feeling angry and irritable could be a symptom of constipation? A horrible fullness and pressing sharp pains against the bladders can’t help but affect your mood. Sometimes you just want everyone to leave you alone and sleep to escape the pain. It is virtually impossible to be constipated and keep a sunny disposition. Follow the steps in this guide to alleviate constipation and lead a happier healthy life.

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