Adverse Effects Contraindications and Drug Interactions

No significant adverse effects to topical penciclovir have been reported. Oral famciclovir is generally well tolerated. Adverse effects include headache, nausea, and diarrhea. Confusion may occur, particularly in the elderly. Hallucinations and urticaria have been reported. Animal studies have indicated that chronic fam-ciclovir administration may be tumorigenic and impair spermatogenesis. Dosage adjustment is necessary in individuals with renal impairment.

Famciclovir may interact with probenecid or other drugs eliminated by renal tubular secretion. This interaction may result in increased blood levels of penci-clovir or other agents.

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