Abuse of Xanthines

The use of some xanthine-containing beverages is customary in most cultures, and moderate use of such beverages does not appear to cause problems in most people. There is little question, however, that such use is habituating. For example, it has been observed that chronic coffee drinkers who suddenly abstain frequently have headaches and a general feeling of fatigue that may last for several days. Although it has not been established that these symptoms constitute any kind of abstinence syndrome, it remains a possibility. There is no good evidence for the development of tolerance to the CNS stimulant effects of caffeine.

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