Absorption Metabolism and Excretion

Ganciclovir can be given orally or intravenously; however, its oral absorption is poor (6-9%). Valganciclovir is well absorbed from the gastrointestinal tract and is rapidly metabolized to ganciclovir. The bioavailability of ganciclovir following valganciclovir administration is approximately 60%. Following intravenous administration, ganciclovir is found in the vitreous humor at concentrations approximately equal to plasma levels. Ganciclovir is not metabolized appreciably and is eliminated by glomerular filtration and active tubular secretion. Its rate of elimination is inversely proportional to creatinine clearance. The terminal half-life of ganci-clovir is approximately 3.5 hours following intravenous administration and 4.8 hours following oral administration. The half-life of ganciclovir following oral valganci-clovir administration is about 4 hours. The intracellular half-life of ganciclovir triphosphate is over 24 hours.

Peripheral Neuropathy Natural Treatment Options

Peripheral Neuropathy Natural Treatment Options

This guide will help millions of people understand this condition so that they can take control of their lives and make informed decisions. The ebook covers information on a vast number of different types of neuropathy. In addition, it will be a useful resource for their families, caregivers, and health care providers.

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