Absorption Metabolism and Excretion

Ganciclovir can be given orally or intravenously; however, its oral absorption is poor (6-9%). Valganciclovir is well absorbed from the gastrointestinal tract and is rapidly metabolized to ganciclovir. The bioavailability of ganciclovir following valganciclovir administration is approximately 60%. Following intravenous administration, ganciclovir is found in the vitreous humor at concentrations approximately equal to plasma levels. Ganciclovir is not metabolized appreciably and is eliminated by glomerular filtration and active tubular secretion. Its rate of elimination is inversely proportional to creatinine clearance. The terminal half-life of ganci-clovir is approximately 3.5 hours following intravenous administration and 4.8 hours following oral administration. The half-life of ganciclovir following oral valganci-clovir administration is about 4 hours. The intracellular half-life of ganciclovir triphosphate is over 24 hours.

Bacterial Vaginosis Facts

Bacterial Vaginosis Facts

This fact sheet is designed to provide you with information on Bacterial Vaginosis. Bacterial vaginosis is an abnormal vaginal condition that is characterized by vaginal discharge and results from an overgrowth of atypical bacteria in the vagina.

Get My Free Ebook

Post a comment