Absorption Metabolism and Excretion

After oral administration, cyclosporine is absorbed slowly and incompletely, with great variation among in dividuals. Peak plasma concentrations are reached in 3 to 4 hours, and the plasma half-life is 10 to 27 hours. The drug is extensively metabolized by hepatic mixed-function oxidase enzymes and is excreted principally via the bile into the feces. Metabolism results in inactiva-tion of the immunosuppressive activity. Agents that enhance or inhibit the mixed-function oxidase enzymes will alter the therapeutic response to cyclosporine.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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