Absorption Metabolism and Excretion

Penciclovir is available as a topical cream; its absorption through the skin is undetectable. Famciclovir is well absorbed following oral administration and is rapidly converted to penciclovir by hepatic first-pass metabolism. The bioavailability of penciclovir following oral famciclovir administration is approximately 77%. Penciclovir is less than 20% bound to plasma proteins.

The plasma elimination half-life for penciclovir is 2 to 3 hours; however, the intracellular half-life of penci-clovir triphosphate is 7 to 20 hours in infected cells. Most penciclovir is eliminated unchanged by the kidney via glomerular filtration and active tubular secretion. The plasma half-life is increased in individuals with renal insufficiency.

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