Absorption Metabolism and Excretion

Amantadine is rapidly and completely absorbed from the gastrointestinal tract, and peak blood levels are achieved in 2 to 5 hours. The serum half-life of amantadine averages 17 hours in young adults and 29 hours in the elderly. Most of the drug (90%) is eliminated unchanged by glomerular filtration and tubular secretion.

Rimantadine is well absorbed following oral administration, with peak blood levels achieved in 5 to 7 hours. Its elimination half-life averages 25 hours in young adults and 32 hours in the elderly. Less than 25% of the dose is excreted in the urine as unchanged drug; the remainder is eliminated as hydroxylated or conjugated metabolites.

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