Absorption Metabolism and Excretion

Amantadine is rapidly and completely absorbed from the gastrointestinal tract, and peak blood levels are achieved in 2 to 5 hours. The serum half-life of amantadine averages 17 hours in young adults and 29 hours in the elderly. Most of the drug (90%) is eliminated unchanged by glomerular filtration and tubular secretion.

Rimantadine is well absorbed following oral administration, with peak blood levels achieved in 5 to 7 hours. Its elimination half-life averages 25 hours in young adults and 32 hours in the elderly. Less than 25% of the dose is excreted in the urine as unchanged drug; the remainder is eliminated as hydroxylated or conjugated metabolites.

Peripheral Neuropathy Natural Treatment Options

Peripheral Neuropathy Natural Treatment Options

This guide will help millions of people understand this condition so that they can take control of their lives and make informed decisions. The ebook covers information on a vast number of different types of neuropathy. In addition, it will be a useful resource for their families, caregivers, and health care providers.

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