Absorption Metabolism and Excretion

Succinylcholine is given systemically because the molecule is charged and does not easily cross membranes. It is rapidly hydrolyzed by plasma cholinesterase to succinyl-monocholine, which is pharmacologically inactive. Because plasma cholinesterase is synthesized in the liver, neuromuscular block may be prolonged in patients with liver disease. About 10% of succinylcholine is excreted unchanged in the urine. The response to succinylcholine may also be prolonged in individuals with a genetic defect leading to atypical plasma cholinesterase (homozygous incidence of about 1 in 2,500). In this case, the enzyme has a decreased affinity for substrates such as succinylcholine that can be measured by the dibucaine test.

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

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