Absorption Metabolism and Excretion

Succinylcholine is given systemically because the molecule is charged and does not easily cross membranes. It is rapidly hydrolyzed by plasma cholinesterase to succinyl-monocholine, which is pharmacologically inactive. Because plasma cholinesterase is synthesized in the liver, neuromuscular block may be prolonged in patients with liver disease. About 10% of succinylcholine is excreted unchanged in the urine. The response to succinylcholine may also be prolonged in individuals with a genetic defect leading to atypical plasma cholinesterase (homozygous incidence of about 1 in 2,500). In this case, the enzyme has a decreased affinity for substrates such as succinylcholine that can be measured by the dibucaine test.

Coping with Asthma

Coping with Asthma

If you suffer with asthma, you will no doubt be familiar with the uncomfortable sensations as your bronchial tubes begin to narrow and your muscles around them start to tighten. A sticky mucus known as phlegm begins to produce and increase within your bronchial tubes and you begin to wheeze, cough and struggle to breathe.

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