Absorption Metabolism and Excretion

Zanamivir has a bioavailability of less than 5% when absorbed through the gastrointestinal tract. It is administered using a breath-actuated inhaler device (Diskhaler)

that delivers the drug as an aerosol in a lactose carrier. The lactose particles are large, and about 78% deposit in the oropharynx. Following oral inhalation, zanamivir has a bioavailability of 12 to 17%, with peak plasma concentrations being reached within 1.5 hours. It is rapidly eliminated by the kidneys without significant metabolism and has a plasma elimination half-life of 2.5 to 5 hours.

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