Absorption Distribution Metabolism and Excretion

Fluconazole (Diflucan) does not require an acidic environment, as does ketoconazole, for gastrointestinal absorption. About 80 to 90% of an orally administered dose is absorbed, yielding high serum drug levels. The half-life of the drug is 27 to 37 hours, permitting once-daily dosing in patients with normal renal function. Only 11% of circulating drug is bound to plasma proteins. The drug penetrates widely into most body tissues, including normal and inflamed meninges. Cerebrospinal fluid levels are 60 to 80% of serum levels, permitting effective treatment for fungal meningitis. About 80% of the drug is excreted unchanged in the urine, and 10% is excreted unchanged in the feces. Dosage reductions are required in the presence of renal insufficiency.

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook


Post a comment