Absorption Distribution Metabolism and Excretion

Food in the stomach does not interfere with the absorption of either clindamycin or lincomycin. Peak serum levels can be obtained 1 hour after intravenous administration of clindamycin, and approximately 90% of the antibiotic is protein bound.

Lincomycin and clindamycin penetrate most tissues well, including bone. Therefore, bone and joint infections caused by susceptible organisms respond well to treatment with clindamycin. These drugs also concentrate within phagocytic cells, which may offer a therapeutic advantage. Lincomycin and clindamycin do not readily penetrate the normal or inflamed meninges. They do, however, pass readily through the placental barrier. Their half-life is 2 to 2.5 hours.

Both clindamycin and lincomycin are metabolized by the liver, and 90% of the inactivated drug is excreted in the urine. If renal function is impaired, the amount of drug excreted in the feces will be increased.

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