■ a-Hydroxytriazolam these compounds in the elderly and in individuals with liver disease seems advisable.

One of the great disadvantages associated with many of the sedative and hypnotic drugs (e.g., barbiturates, propanediol carbamates), which have now largely been replaced by the benzodiazepines, is the fact that those drugs are very effective inducers of hepatic drug-metabolizing enzymes. Since the benzodiazepines are only weak inducers of hepatic microsomal enzymes, they cause relatively few clinically significant drug interactions related to metabolism of other drugs.

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