General Comments

The No Nonsense Teds Fat Melting

Eat More Diet Less

Get Instant Access

Cobalt is an essential trace element. It occurs in vitamin B12, which is required by all mammals for hemoglobin synthesis. In humans and all other monogastric species, B12is the only bioavailable form of cobalt, since these organisms are unable to synthesize the vitamin from dietary cobalt. Uptake of cobalt from the diet, therefore, must be in the form of vitamin B12 (1), which is also suspected to exacerbate, if not induce, cobalt allergy (2).

Cobalt compounds can pose significant dermal and respiratory toxicity problems, primarily in industry, due to their allergenic potential (3,4) and as causative factors for hard metal disease, a particular form of pneumoconiosis (5). Occurrence of the latter, ranging in form from intense alveolitis to end-stage pulmonary fibrosis, appears to require concomitant exposure to other agents, including tungsten metal dust (6,7). It is prevalent among workers exposed to metal-containing, respirable dust generated in the production and use of hard metal cutting tools. Evidence of cobalt carcinogenicity in humans is inadequate and cannot be evaluated quantitatively (7).

B. SKIN ABSORPTION, ELIMINATION, AND REACTIVITY

The human stratum corneum appears to be an effective barrier to cobalt penetra- s tion. In guinea pigs, in vivo, on the other hand, percutaneous toxicity of cobalt J

was considerable, based on the observation that 11 of 20 animals died within 2 o weeks of continuous dermal exposure (8). Skin absorption of the metal also de- |

pends on the respective counterion with chloride > tartrate > hydroxide (9). |

Hair analysis is seen as a suitable method for biological monitoring of exposure to the metal in the work environment, as atomic absorption analysis revealed geometrical mean values for cobalt in exposed workers to be signifi- <->

Was this article helpful?

0 0
Spiritual Weight Loss Mentality

Spiritual Weight Loss Mentality

Awesome Ways To Get Over Your Mentality That Keeps you Overweight! This Book Is One Of The Most Valuable Resources In The World When It Comes To Results In Your Slim-down and Health Efforts! Day in day out we keep ourselves absorbed with those matters that matter the most to us. A lot of times, it might be just to survive and bring in some money. In doing so we at times disregard or forget about the extra matters that are essential to balance our lives. They’re even more essential to supply real meaning to our world. You have to pay attention to your wellness.

Get My Free Ebook


Post a comment