Transdermal Oxybutynin

Approved by the U.S. Food and Drug Administration (FDA) in 2003, transdermal oxybutynin is a matrix-type patch system (OxytrolTM; Watson Pharma, Inc.) that provides 3.9 mg of oxybutynin per day via twice-weekly applications.

In a phase III double-blind, placebo-controlled study comparing 3.9 to 1.3 and 2.6mg/d transdermal oxybutynin as well as placebo patch, the 3.9-mg daily dose of transdermal oxybutynin significantly decreased weekly incontinence episodes and urinary frequency, increased voided volumes, and significantly improved quality of life (Incontinence Impact Questionnaire total score, P = .0327) compared with placebo.1

The most common adverse event with the transdermal system is application-site pruritus (transdermal oxybutynin, 16.8%; placebo, 6.1%).1 The incidence of dry mouth in the transdermal group was similar to placebo (9.6% vs. 8.3%).1 The dosage of oxybutynin is dependent on the surface area of the applied patch. We have noted that many patients who benefit from 10mg of Ditropan XL may need 1 to 2 patches to achieve a similar reduction in OAB symptoms.

When we initiate oxybutynin therapy, we will offer patients either 10 mg of Ditropan XL or a 3.9-mg patch. Depending on the response, tolerability, and other factors, some patients may increase the dosage to 15 mg of Ditropan XL or 1.5 to 2 patches weekly. Alternatively, patients may supplement the oxybutynin dosage by adding 2.5 to 5mg of immediate-release oxybutynin as necessary for a social event or travel. As with any anticholinergic agent, it is contraindicated in patients with narrow-angle glaucoma, severe constipation, or an allergy to the medication.

Constipation Prescription

Constipation Prescription

Did you ever think feeling angry and irritable could be a symptom of constipation? A horrible fullness and pressing sharp pains against the bladders can’t help but affect your mood. Sometimes you just want everyone to leave you alone and sleep to escape the pain. It is virtually impossible to be constipated and keep a sunny disposition. Follow the steps in this guide to alleviate constipation and lead a happier healthy life.

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