Toxic Substances in Urine

The idea that the urine of IC patients carries a pathologic substance accounting for the disorder has been suggested. The initial observation that the urine of IC patients may contain pathologic substances was suggested when it was found that it inhibits the proliferation of cultured human transitional cells. Keay et al.29 determined that the urine of IC patients specifically contains a low-molecular-weight protein factor that inhibits bladder epithelium proliferation, an antiproliferative factor (APF).

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