Potassium Sensitivity Test

The potassium sensitivity (KCl) test was developed by Parsons et al.12,15 as a method to diagnose IC. This test is based on the assertion that bladder epithelium is leaky in IC patients. Potassium in the urine crosses the urothelium to the submucosa and muscle layer, causing sensory nerve irritation and inflammation. The IC committee in 2003 did not recommend KCl test because neither high sensitivity nor specificity has been established,2 and at our institution, KCl test is also not routinely used in evaluation of IC patients.

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