Pentosan polysulfate is a highly sulfated synthetic polysac-charide similar in structure to heparin sulfate, which is one of the GAG constitutes of the BSM. When taken orally,
2% to 6% of pentosan polysulfate sodium is excreted unchanged in the urine. The response to treatment varies from 28% to 32%.41,42 The dosage is 100mg three times a day. The medication is generally well tolerated with adverse reaction rates varying from 1% to 4%.43 The most common reported adverse effect is dyspepsia. Other uncommon reactions include reversible alopecia and increased bruising.
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