Attempts to show an infectious etiology go back to the dawn of the disease, but the case has never been a strong one. Bacterial, viral, and fungal studies were performed on IC patients, and they failed to substantiate an infectious eti ology. Infection with "atypical" or fastidious organisms has been proposed by numerous investigators. Some studies showed isolation of fastidious bacteria and Ureaplasma urealyticum.6-8 Although absence of bacterial DNA was reported, presence of bacterial 16Sr RNA was found in the bladder biopsies of some IC patients.9,10 Domingue and Ghoniem11 suggested that even if the organisms are not causative agents, their presence might lead to immune and host-cell responses that could initiate or exacerbate an inflammatory state.
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