In early female gestation, the cloaca separates into anterior and posterior divisions. The anterior division develops into the urogenital sinus. This endodermal structure then morphs into the bladder, urethra, and vaginal bulb. The bulb forms a portion of the superior vagina and inferiorly fuses with the genital ectoderm. This fusion point forms the vulvar vestibule.
The common embryologic origin of the vestibule, urethra, and bladder has suggested an etiologic association among chronic painful conditions involving these tissues. This may help explain the similarity in physical and histologic findings, prevalence rates, and treatment strategies for vulvar vestibulitis, trigonitis, urethritis, and interstitial cystitis.1,2 Interstitial cystitis is considered in a separate chapter.
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Did you ever think feeling angry and irritable could be a symptom of constipation? A horrible fullness and pressing sharp pains against the bladders can’t help but affect your mood. Sometimes you just want everyone to leave you alone and sleep to escape the pain. It is virtually impossible to be constipated and keep a sunny disposition. Follow the steps in this guide to alleviate constipation and lead a happier healthy life.