Capsaicin and Resiniferatoxin

Capsaicin is the pungent component of the hot pepper. Chronic application is known to be associated with C fiber (unmyelinated nerve fibers known for transmitting painful stimuli) desensitization. Reports on the success vary because of the use of different concentrations. The main drawback of capsaicin is a severe burning sensation, which is described by the patients despite the preinstillation of anesthetic. Resiniferatoxin, which is an analog of capsaicin has no irritative or burning symptom, but is 100 to 10000 times more potent than capsaicin.

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