Bulking Agents

The ideal bulking agent must be hypoallergenic, biocompatible, and nonimmunogenic. Additional considerations for selecting a particular agent include cost, implant handling and storage, special equipment for injection, technical ease of application, local and distal migration of the material, and tissue reaction such as inflammation and wound healing. The bulking agents currently approved in the US by the Food and Drug Administration (FDA), include GAX collagen, autologous fat, and carbon-coated beads and are reviewed below.

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