This domain contains several His residues , which may act as anchoring sites to bind Cu2+ ions (Fig. 14) . There are some indications that a pep-tide corresponding to the second helical region of the human PrP shows some ability to form fibrils and it possesses a Cu2+-mediated neurotoxicity . The abnormal interactions with model membranes may also have some impact on the neurotoxicity of this fragment .
His187 acts as an anchoring site for Cu2+ ions and the binding motif seems to be similar to those found in the other fragments of mammalian PrP .
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