Figure 13. Model of PrP 57-231 showing the binding sites of Cu2+ ions. (Reproduced by permission from [49]).

This domain contains several His residues [52], which may act as anchoring sites to bind Cu2+ ions (Fig. 14) [31]. There are some indications that a pep-tide corresponding to the second helical region of the human PrP shows some ability to form fibrils and it possesses a Cu2+-mediated neurotoxicity [53]. The abnormal interactions with model membranes may also have some impact on the neurotoxicity of this fragment [54].

His187 acts as an anchoring site for Cu2+ ions and the binding motif seems to be similar to those found in the other fragments of mammalian PrP [55].

Was this article helpful?

0 0
Detoxify the Body

Detoxify the Body

Need to Detoxify? Discover The Secrets to Detox Your Body The Quick & Easy Way at Home! Too much partying got you feeling bad about yourself? Or perhaps you want to lose weight and have tried everything under the sun?

Get My Free Ebook

Post a comment