Metal Ions in Life Sciences

It is an old wisdom that metals are indispensable for life. Indeed, several of them, like sodium, potassium, and calcium, are easily discovered in living matter. However, the role of metals and their impact on life remained largely hidden until inorganic chemistry and coordination chemistry experienced a pronounced revival in the 1950s. The experimental and theoretical tools created in this period and their application to biochemical problems led to the development of the field or discipline now known as Bioinorganic Chemistry, Inorganic Biochemistry, or more recently also often addressed as Biological Inorganic Chemistry.

By 1970 Bioinorganic Chemistry was established and further promoted by the book series Metal Ions in Biological Systems founded in 1973 (edited by H.S., who was soon joined by A.S.) and published by Marcel Dekker, Inc., New York, for more than 30 years. After this company ceased to be a family endeavor and its acquisition by another company, we decided, after having edited 44 volumes of the MIBS series (the last two together with R.K.O.S.) to launch a new and broader-minded series to cover today's needs in the Life Sciences. Therefore, the Sigels' new series is entitled

Metal Ions in Life Sciences and we are happy to join forces in this new endeavor with a most experienced publisher in the Sciences, John Wiley & Sons, Ltd, Chichester, UK.

The development of Biological Inorganic Chemistry during the past 40 years was and still is driven by several factors; among these are: (i) the attempts to reveal the interplay between metal ions and peptides, nucleotides, hormones or vitamins, etc.; (ii) the efforts regarding the understanding of accumulation, transport, metabolism and toxicity of metal ions; (iii) the development and application of metal-based drugs; (iv) biomimetic syntheses with the aim to understand biological processes as well as to create efficient catalysts; (v) the determination of high-resolution structures of proteins, nucleic acids, and other biomolecules; (vi) the utilization of powerful spectroscopic tools allowing studies of structures and dynamics; and (vii), more recently, the widespread use of

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