Metal Ion Binding Properties of Proteins Related to Neurodegeneration

Henryk Kozlowski,1 Marek Luczkowski,1 Daniela Valensin,2 and

Gianni Valensin2

1Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383 Wroclaw, Poland <[email protected]> <[email protected]>

2Department of Chemistry, University of Siena, via Aldo Moro, 53100, Siena, Italy <[email protected]>

1 INTRODUCTION 62

2 Cu2+ INTERACTIONS WITH MAMMALIAN PRION

PROTEINS AND THEIR FRAGMENTS 63

2.1 Structures of Mammalian Prion Proteins and the Potential

Metal Ion Binding Sites 63

2.2 Cu2+ Ion Binding to the Mammalian Prion Protein

Octapeptide Repeat Fragment 64

2.3 Binding of Cu2+ to Longer Octarepeat Fragments 67

2.4 Binding of Cu2+ by Chicken Prion Tandem Repeats 70

2.5 Cu2+ Binding to the Neurotoxic Prion Protein Fragment 70

2.6 Interaction of Cu2+ Ions with Globular Domain of the Prion Protein 73

2.7 The Binding of Cu2+ Ions and Superoxide Dismutase Activity of Prion Protein 74

2.8 Affinity of the Prion Protein to Bind Cu2+ Ions 75

3 INTERACTIONS OF METAL IONS WITH THE AMYLOID PRECURSOR PROTEIN AND ITS FRAGMENTS 76

3.1 Interactions of Metal Ions with the ß-Amyloid Peptide 76

3.2 Metal Ion Binding Sites in the Cysteine Region of the

Amyloid Precursor Protein 80

Metal Ions in Life Sciences, Volume 1 Edited by Astrid Sigel, Helmut Sigel and Roland K. O. Sigel © 2006 John Wiley & Sons, Ltd

4 CONCLUDING REMARKS ACKNOWLEDGMENTS ABBREVIATIONS REFERENCES

82 83 83 83

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