The appreciation of the role of metallobiology in neuroscience and in neurology is increasing rapidly. In Chapter 1 of this volume we organized the metal-related neurological disorders into: (i) those caused by a defect in metal ion transport or homeostasis; (ii) those caused by toxicological exposure to metal; and (iii) those caused or associated with metalloprotein aggregation. While this scheme has some organizational value, its value for medical practice will be determined by its ability to guide the practitioner to practical therapeutics. While truly specific and potent metal-centered pharmaceuticals for these diseases currently lie ahead of us, there is progress being made.
Additionally, there are other neurological conditions that have not been covered in detail in this volume (see below) which may have aspects of their pathophysiology related to metallochemistry that may also be amenable to metal-centered pharmacological approaches.
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