Shortly after MPTP was found to provoke a parkinsonian syndrome in humans, researchers were prompted to test MPTP toxicity in a variety of animal species including monkeys, dogs, cats, and rodents (21,22). These investigations showed that most of the vertebrates and invertebrates tested were sensitive to the neurotoxic effects of MPTP (21,22), but with marked differences among species. Among mammals, monkeys, for example, were by far the most sensitive to MPTP whereas rats and guinea pigs were resistant and mice were of intermediate susceptibility.
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