Levodopa is an intermediary metabolite in the synthesis of melanin. For this reason, there has been long-standing concern that this medication might potentially promote the growth of melanoma. While melanoma obviously occurs in patients on levodopa therapy, there is no evidence that the incidence differs from that in the general population (96-99), other than that there seems to be a higher risk for melanoma in patients with PD, even without levodopa treatment (100). In studies of patients with melanoma, levodopa exposure is rare (101). Thus, although the package insert warns that levodopa should not be used in patients with melanoma or suspicious skin lesions (102-105), there is no clinical evidence to support this admonition (106-109). Nonetheless, in patients with PD and a history of melanoma, it would seem prudent to both defer levodopa therapy until other medications prove inadequate and to monitor closely for recurrent melanoma.
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Complete Guide to Preventing Skin Cancer. We all know enough to fear the name, just as we do the words tumor and malignant. But apart from that, most of us know very little at all about cancer, especially skin cancer in itself. If I were to ask you to tell me about skin cancer right now, what would you say? Apart from the fact that its a cancer on the skin, that is.