Sulfadiazine or trisulfapyrimidines have similar activity in combination with pyrimethamine. Most other sulfonamides are inferior. The usual oral dose is 50-100 mg/kg daily with a double loading dose. The general recommendation is at least 4g/day. The patient must maintain a good urine output to avoid crystalluria and oliguria. Alkalization of the urine with sodium bicarbonate may also reduce the chance of crystalluria in AIDS patients. Today no evidence exists that sulfonamides may cause foetal abnormalities (Briggs et al. 1994).

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