Drugs

Until today the drugs used regularly for treatment of toxoplasmosis act by slowing down the multiplication of tachyzoites, either by interfering with protein synthesis or by inhibition of vital enzymes (Derouin 2000). Only four drugs have been used to a great extent: pyrimethamine, sulfonamide, spiramycin, and clindamycin (WHO 1990). These drugs do not eliminate the Toxoplasma tissue cysts, nor do they prevent new tissue cyst formation. Today in the AIDS era there is an urgent need for developing and trying new drugs which may affect the cystic stage. Azithromycin and atovaquone seem promising in animal models, and have shown remarkable acitivity against the tissue cysts in vitro (Huskinson et al. 1991). These drugs are now on trial in individuals with AIDS and ocular toxoplasmosis.

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