Diagnosis of cerebral toxoplasmosis

Screening for antibodies against T. gondii is recommended in HIV-positive persons, new cases of certain cancers, for example, hairy-cell leukaemia, and before transplantation to check whether the individual harbours the Toxoplasma parasite. If the person is sero-positive there is a risk of developing cerebral toxoplasmosis during the progress of the disease. Lack of specific antibodies against Toxoplasma in patients with CNS symptoms speak against cerebral toxoplasmosis, while the presence of these antibodies in a patient with CNS symptoms can support the diagnosis. Cerebral toxoplasmosis is rarely followed by an altered serological response, that is, an increase in IgG or IgM antibodies.

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