Cotrimoxazole

Trimethoprim and sulfamethxazole is a combination of drugs with comparable half-life. Experimental data and animal studies indicate that administration of cotrimoxazole to Toxoplasma gondii-infected pregnant mice gives a better in utero control of congenital toxoplasmosis than does spiramycin (Nguyen and Stadtsbader 1985). In humans the efficacy has been established for the prophylaxis of Pneumocystis carinii and T.gondii infections in patients with AIDS and has resulted in a marked reduction of the incidence of cerebral toxoplasmosis (Berlanger et al. 1999). In addition, for the treatment of Toxoplasma encephalitis the combination (trimethoprim 10mg/kg/day and sulfamethxazole 50mg/kg/day) was as effective and better tolerated than the standard pyrimethamine/sulfadiazine regimens (Torre et al. 1998).

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