The deletion is associated with an increased risk of lung, larynx, prostate, cervical, and bladder cancers (34,80,86-89), and asthma (90). When broccoli consumption was factored into a study of the incidence of colorectal adenomas, a protective effect was observed in GSTT1 (—/ —) with individuals consuming highest amounts of broccoli (91).
Oxidative Stress and Human Genetic Variation ENDOTHELIAL NITRIC OXIDE SYNTHASE
Gene: eNOS—Endothelial Nitric Oxide Synthase (NOS3) Polymorphisms: G894T—Glu298Asp
• Function: Nitric oxide production which is implicated in relaxation of vascular muscle
• Biochemical activity: L-Arginine + N NADPH + M O2 = citrulline + nitric oxide + N NADP+
• Structure: Homodimer
• Location: Platelets
• Population frequency: 29% Caucasion, 9% Japanese
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