GSTT1 and Health Conditions

Cancer

The deletion is associated with an increased risk of lung, larynx, prostate, cervical, and bladder cancers (34,80,86-89), and asthma (90). When broccoli consumption was factored into a study of the incidence of colorectal adenomas, a protective effect was observed in GSTT1 (—/ —) with individuals consuming highest amounts of broccoli (91).

Oxidative Stress and Human Genetic Variation ENDOTHELIAL NITRIC OXIDE SYNTHASE

Gene: eNOS—Endothelial Nitric Oxide Synthase (NOS3) Polymorphisms: G894T—Glu298Asp

• Function: Nitric oxide production which is implicated in relaxation of vascular muscle

• Biochemical activity: L-Arginine + N NADPH + M O2 = citrulline + nitric oxide + N NADP+

• Structure: Homodimer

• Location: Platelets

• Population frequency: 29% Caucasion, 9% Japanese

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