Transcriptional Regulation of Cellular Antioxidant Defense Mechanisms

YOUNG-JOON SURH

National Research Laboratory, College of Pharmacy, Seoul, National University,

Seoul, South Korea

Reactive oxygen species (ROS) are constantly generated in human body. Enzymatic and nonenzymatic antioxidants detoxify ROS and minimize damage to biomolecules. An imbalance between the production of ROS and cellular antioxidant capacity leads to a state of "oxidative stress'' that contributes to the pathogenesis of a vast variety of clinical abnormalities (1-3). The susceptibility of the target organs or cells to oxidative injury depends largely on their capability to control protective ROS scavenging systems. The primary endogenous antioxidants are present normally at low levels in human tissues and are not timely induced when exposed to oxidative

stress. However, the response of certain antioxidant enzymes, constituting the critical primary defense against exogenous oxidative stress, occurs rapidly in proportion to oxidant insult. This chapter focuses on molecular aspects of adaptive cytopro-tection in response to oxidative stress.

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Detox Diet Basics

Detox Diet Basics

Our internal organs, the colon, liver and intestines, help our bodies eliminate toxic and harmful  matter from our bloodstreams and tissues. Often, our systems become overloaded with waste. The very air we breathe, and all of its pollutants, build up in our bodies. Today’s over processed foods and environmental pollutants can easily overwhelm our delicate systems and cause toxic matter to build up in our bodies.

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