Mapt

Polymorphism,

H1/H1

genotype

Tau (4R) (Exon 10)

H1/H1 haplotype

Multiple system degeneration, balloned neurons, tau plaques

Parkinsonism, apraxia, dementia

Argyrophilic grain disease (AGD)

A2M-gene, LPR-gene

?

Tau (4R), tau haplotype

Advanced age,

ApoE e4

Frontotemporal atrophy, Pick bodies, Pick cells, hippocampal atrophy, argyrophilic grains ± Alzheimer or other pathologies

Mild cognitive impairment, normal cognition or dementia

Frontotemporal dementia + parkinsonism (FTDP 17)

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