This table was refined and some additions were made from the original one from (11). MPTP mice model is indicated in black; Methamphetamine mice is indicated red; 6-OHDArat model is indicated in blue. The MPTP mice models were obtained by injecting once male C57-BL mice with 50 mg/kg MPTP, i.p., (controls received saline). The i.p., (controls received saline) over 8 days. Mice were sacrificed after 24 h or 7 days of final neurotoxicant dose (37,38). The methamphetamine mice model were obtained by injecting once male C57-BL mice with 40 mg/kg methamphetamine, i.p., (controls received saline). The animals were sacrificed after 3, 6, 12 and 24 h after treatment (48). Or in male CD-1 mice injected with single dose of 40 mg/kg methamphetamine (controls received saline). Mice were sacrificed after 2, 4 and 16 h after neurotoxin injection (47).

The 6-OHDA rat model were obtained via unilateral nigrostriatal injection of 8 ^g/4 ^l 6-OHDA (controls received saline.) Rats were sacrificed 20 days after lesion (42).

UP-regulated gene f, Down-regulated gene \ all compared to control animals.

Abbrevgiations: Cyclooxygenase-1, COX-1; Growth arrest and DNA-damage inducible, GADD; Glial cell line-derived neurotrophic factor, GDNF; Heat shock protein, HSP; Inducible nitric oxide synthase, iNOS; Interleukin, IL; JUN N-terminal kinase, JNK; Mitogen-activated protein kinase kinase, MKK; N-methyl-4-phenyl-1,2,3,6-tetrahydropyidine, MPTP; 6-hydroxydopamine, 6-OHDA; Nuclear factor kB, NF-kB; Platelet-derived growth factor, PDGF; Tyrosine hydroxylase, TH; Solute carrier, SLC; cAMP responsive element modulator, Crem; Angiopoietin, Agpt; Chemokine (C-C) receptor, CCr; Cyclin-dependent kinase, CDK; Janus tyrosine-protein kinase, JAK; Dopamine transporter, DAT; Ubiquitin carboxyl-terminal hydrolase, UCHL1.

Drug Addiction Report

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