Info

Parkin

Rigidity, akinesia, tremor, instability (dementia)

Dementia with Lewy bodies (DLBs), Parkinson with dementia (PDD)

a-Synuclein

Not identified

a-Synuclein

ApoE e2

Cortical and subcortical Lewy bodies, nigral degeneration, Alzheimer pathology

Progressive dementia, parkinsonism, visual hallucinations, neuroleptic sensivity

LB variant of AD (LBV/AD)

a-Synuclein (tau ?)

?

a-Synuclein, tau

ApoE e4?

Lewy bodies + neurites, AD pathology (plaques, tangles), PHF-tau

Progressive dementia, parkinsonism

Multiple system atrophy (MSA)

a-Synuclein (multiplication), no relation to UCHL-1

Unknown

a-Synuclein

Not identified

Striatonigral/ olivopontocerebellar atrophy, glial cytoplasmic inclusions (GCI)

Parkinsonism

(MSA-P), cerebellar ataxia

(MSA-C), autonomic disorders

HallervordenSpatz disease (neurodegeneration with brain iron accumulation, type I - NBIA-1)

Pantothenate kinase 2 (PANK 2)

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