Conclusion

In conclusion, studies on gene expression alterations reveal a wide range of pathways involved in neurodegeneration which might help to unravel the aetiologies of the diseases and in the future development of new therapies for prevention . However, more studies are required. These studies should be directed at using similar tissue sampling and the gene expression should be confirmed with quantitative-RT-PCR as well as proteomic profiling. One inherent problem with gene expression studies is that not all gene expression changes can be associated with the specific protein they initiate.

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