This work was supported by grant CA112593 from the US National Institutes of Health. REFERENCES

1. Stone HB, Coleman CN, Anscher MS, McBride WH. Effects of radiation on normal tissue: consequences and mechanisms. Lancet Oncol. 4: 529-536, 2003.

2. Coleman CN, Stone HB, Moulder JE, Pellmar TC. Modulation of radiation injury. Science 304: 693-694, 2004.

3. Jemal A, Siegel A, Ward E, Murray T, Xu J, Smigal C, Thun MJ. Cancer statistics. CA Cancer J Clin. 56: 106-130, 2006.

4. Patchell RA. The management of brain metastases. Cancer Treat Rev. 29: 533-540, 2003.

5. Shaw EG, Robbins ME. The management of radiation-induced brain injury. Cancer Treat Res. 128: 7-22, 2006.

6. Withers HR, Peters LJ, Kogelnik HS. The pathobiology of late effects in irradiation. In: Radiation Biology in Cancer Research (Meyn RE, Withers HR, eds.). Raven Press, NY, pp. 439-448, 1980.

7. Rubin P, Casarett GW. Clinical Radiation Pathology. W.B. Saunders Co, Philadelphia, 1968.

8. Jaenke RS, Robbins MEC, Bywaters T, Whitehouse E, Rezvani M, Hopewell JW. Capillary endothelium: target site of renal radiation injury. Lab Invest. 57: 551-565, 1993.

9. Schultheiss TE, Stephens LC. Permanent radiation myelopathy. Br J Radiol. 65: 737-753, 1992.

10. Rubin P, Finkelstein J, Shapiro D. Molecular biology mechanisms in the radiation induction of pulmonary injury syndromes: interrelationship between the alveolar macrophages and the septal fibroblast. Int J Radiat Oncol Biol Phys. 24: 93-101, 1992.

11. Denham JW, Hauer-Jensen M. The radiotherapeutic injury - a complex "wound." Radiother Oncol. 63: 129-145, 2002.

12. Dent P, Yacoub A, Contessa J, Caron R, Amorino G, Valerie K, Hagan MP, Grant S, Schmidt-Ullrich R. Stress and radiation-induced activation of multiple intracellular signaling pathways. Radiat Res. 159: 283-300, 2003.

13. Moulder J, Robbins MEC, Cohen EP, Hopewell JW, Ward WF. Pharmacologic modification of radiation-induced late normal tissue injury. In: Radiation Therapy (Mittal BB, Purdy JA, Ang KK, eds.). Kluwer, Norwell, MA, pp. 129-151, 1998.

14. Moulder JE. Post-irradiation approaches to treatment of radiation injuries in the context of radiological terrorism and radiation accidents: a review. Int J Radiat Biol. 80: 3-10, 2004.

15. Robbins MEC, Zhao W. Chronic oxidative stress and radiation-induced late normal tissue injury: a review. Int J Radiat Biol. 80: 251-259, 2004.

16. Tofilon PJ, Fike JR. The radioresponse of the central nervous system: a dynamic process. Radiat Res. 153: 357-370, 2000.

17. Crossen JR, Garwood D, Glatstein E, Neuwelt EA. Neurobehavioral sequelae of cranial irradiation in adults: a review of radiation-induced encephalopathy. J Clin Oncol. 12: 627-642, 1994.

18. Imperato JP, Paleologos NA, Vick NA. Effects of treatment on long-term survivors with malignant astrocytomas. Annals Neurol. 28: 818-822, 1990.

19. Johannesen TB, Lien HH, Hole KH, Lote K. Radiological and clinical assessment of long-term brain tumour survivors after radiotherapy. Radiother Oncol. 69: 169-176, 2003.

20. van der Maazen RWM, Kleiboer BJ, Berhagen I, van der Kogel AJ. Repair capacity of adult rat glial progenitor cells determined by an in vitro clonogenic assay after in vitro or in vivo fractionated irradiation. Int J Radiat Biol. 63: 661-666, 1993.

21. Calvo W, Hopewell JW, Reinhold HS, Yeung TK. Time- and dose-related changes in the white matter of the rat brain after single doses of X-rays. Br J Radiol. 61: 1043-1052, 1988.

22. Reinhold HS, Calvo W, Hopewell JW, van den Berg AP. Development of blood vessel-related radiation damage in the fimbria of the central nervous system. Int J Radiat Oncol Biol Phys. 18: 37-42, 1990.

23. Morris GM, Coderre JA, Bywaters A, Whitehouse E, Hopewell JW. Boron neutron capture irradiation of the rat spinal cord: histopathological evidence of a vascular-mediated pathogenesis. Radiat Res. 146: 313-320, 1996.

24. Mildenberger M, Beach TG, McGeer EG, Ludgate CM. An animal model of prophylactic cranial irradiation: histologic effects at acute, early and delayed stages. Int J Radiat Oncol Biol Phys. 18: 1051-1060, 1990.

25. Gaber MW, Sabek OM, Fukatsu K, Wilcox HG, Kiani MF, Merchant TE. Differences in ICAM-1 and TNF-a expression between large single fraction and fractionated irradiation in mouse brain. Int J Radiat Biol. 79: 359-366, 2003.

26. Brown WR, Thore WR, Moody DM, Robbins ME, Wheeler KT. Vascular damage after fractionated whole-brain irradiation in rats. Radiat Res. 164: 662-668, 2005.

27. Fowler JF. Brief summary of radiobiological principles in fractionated radiotherapy. Semin Radiat Oncol. 2: 16-21, 1992.

28. Bell MA, Scarrow WG. Staining for microvascular alkaline phosphatase in thick celloidin sections of nervous tissue: morphometric and pathological applications. Microvasc Res. 27: 189-203, 1984.

29. Raff MC, Miller RH, Noble M. A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium. Nature 303: 390-396, 1983.

30. van der Maazen RWM, Kleiboer BJ, Verhagen I, van der Kogel AJ. Irradiation in vitro discriminates between different O-2A progenitor cell subpopulations in the prenatal central nervous system of rats. Radiat Res. 128: 64-72, 1991.

31. van der Maazen RWM, Verhagen I, Kleiboer BJ, van der Kogel AJ. Radiosensitivity of glial progenitor cells of the prenatal and adult rat optic nerve studies by an in vitro clonogenic assay. Radiother Oncol. 20: 258-264, 1991.

32. Hornsey S, Myers R, Coultas PG, Rogers MA, White A. Turnover of proliferative cells in the spinal cord after irradiation and its relation to time dependent repair of radiation damage. Br J Radiol. 54: 1081-1085, 1981.

33. Anscher MS, Vujaskovic Z. Mechanisms and potential targets for prevention and treatment of normal tissue injury after radiation therapy. Semin Oncol. 32(Suppl. 3): S86-S91, 2005.

34. Ransom B, Behar B, Nedergaard M. New role for astrocytes (stars at last). Trends Neurosci. 26: 520-522,

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