Seven Secrets To Reverse Your Osteopenia

The Osteoporosis Reversing Breakthrough

eres just a few things youll learn about how to get back into health. and conquer Osteoporosis. Those not-so innocent yet everyday substances that are currently attacking your body, perpetuating and aggravating your Osteoporosis. What to do and what Not to do to overcome your Osteoporosis effectively and permanently. How to create the energy you need to be able to work full time and feel confident you will be able to take care of your loved ones. How the pharmaceutical and food industry are conspiring to poison you and make you sick (Hint: American medical system is now the leading cause of death in the US). Which food industries use advertising to encourage doctors to tell you that their food is good for you just like those cigarette ads in the 1950s! The single most effective fruits and vegetables in cleaning up excess acidic waste and how to cleanse your inner terrain completely from systemic acidosis. Why, what your Doctor has told you is wrong, and why many medications actually increase the side effects and complications of Osteoporosis (primarily by depleting vital vitamins, minerals and nutrients from your body). Which supplements every patient must take to stop the symptoms and boost your body's ability to reverse Osteoporosis. How to naturally reduce your cravings for toxic foods. Lifestyle and food choices to reverse your Osteoporosis fast, naturally, and for good. Why treating the symptoms of disease is like using an umbrella inside your house instead of fixing the roof. The most powerful creator of health (Hint: its not a food or vitamin!) The best way to simplify the task of making a health-conscious lifestyle adjustment. A miraculous scientific discovery that jump-starts your body to do its natural work, which is to heal itself and restore your Health.

The Osteoporosis Reversing Breakthrough Summary


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Author: Matt Traverso
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Drug Induced Osteopenia

Chronic administration of many drugs, especially anti-convulsant medications, glucocorticoids, and GnRH agonists, are known to produce osteopenia and osteoporosis. The anticonvulsants inhibit formation of active D3 chronic glucocorticoid therapy increases bone turnover by altering osteoblast differentiation and inhibiting collagen synthesis and the GnRH agonists induce chemical hypogonadism. Clinical trials have demonstrated that the use of the bisphosphonates, nasal calcitonin, or human rPTH combined with calcium and vitamin D supplementation is effective in preventing drug-induced osteoporosis. Thus, individuals receiving over the long term any medication that can induce osteomalacia should also take one of these compounds and have periodic bone density determinations.


Bone loss in women accelerates at the onset of menopause on average at a rate of approximately 3 per year for the first 5 years and 1 per year thereafter. Hip fractures frequently occur 15-25 years after menopause and result from the reduced bone mass. Other fractures associated with osteoporosis include fractures of the vertebrae, distal forearm, and proximal humerus. 2. Osteoporosis is diagnosed when bone mineral density decreases to less than 2.5 standard deviations below the young adult peak mean. Estrogen therapy has been shown to be effective in preventing bone loss.

Steroid Free Immunosuppression

Rather than weaning from maintenance steroids, it may be simpler and more effective to start with a potent regimen that combines antibody and drugs but either restricts post transplant corticosteroids to a few days or avoids them altogether. In 2000, 2001 and 2002 more than ten centers for kidney, kidney pancreas and islet transplantation reported excellent outcomes with up to five-year follow-up with regimens that excluded steroids completely or discontinued them within the first post-transplant week (17-22,25-33). Most of the regimens combine drugs with an antibody. Incidence of acute rejection episodes during the first year was 10-15 percent or less. Graft function up to four years was equal to or better than steroid regimens. An earlier 1997 report that compared three cyclosporine-based regimens in kidney recipients showed increased vertebral bone density during the first 18 post-transplant months for cyclosporine alone but decreased vertebral density for cyclosporine plus...

Hormonally Mediated Events

Menopause may cause uncomfortable symptoms in many women and can be controlled to a great extent by HRT. Some of these symptoms, hot flashes, fatigue, and bone thinning (leading to osteoporosis) can intensify symptoms and problems related to MS. Osteoporosis has been linked to the treatment of MS with steroids, and this condition may worsen during the peri-menopausal or menopausal state of life. Unfortunately, there is some controversy in the medical community about the benefit risk ratio of HRT and women should consult their personal physician and gynecologist to discuss the pros and cons of these medications. There are other reasons your physician might suggest HRT for a person with MS, as they can reduce post-menopausal complications that include osteoporosis, weight gain, fatigue, vaginal dryness, diminished libido, increased cardiovascular disorders, and decreased exercise tolerance.

Image Measurement And Quantification

Two examples of physical measurement application are bone mineral densito-metry (BMD) and mammographic density measurement. BMD is a method to quantify the bone mass in the body (16). Osteoporosis is a common bone disease, which makes bone fragile and easy to fracture. Future risk of fracture can be predicted through a BMD measurement. Mammographic density measurement is a tool to measure the regions of brightness associated with fibroglandular tissues in the mammography, which is directly linked with the breast cancer risk. Mammographic density can be computed from the mammography using histogram analysis, or fractal analysis (17,18).

S Evidence statements Steroids

The effectiveness of steroids in the long-term treatment of MS was investigated in one systematic review (Ia), six RCTs (Ib) and one CCT (IIa). The review117 included four placebo-controlled RCTs comparing the effects of ACTH (n 1), prednisolone (n 1) and methyl-prednisolone (n 2) given for 9-18 months. It reported no significant effect on long-term functional improvement or on relapse occurrence. The review also reported the occurrence of both major and minor side effects including herpes simplex, herpes zoster, severe ankle oedema, femur fracture, acute anxiety and severe depression.117 Four of the controlled trials also compared steroids to placebo. Two RCTs, one of ACTH and the other of two different doses of zinc hydroxide corticotrophin, found no effect of treatment on any of the outcomes investigated.142,143 One reported a greater incidence of adverse effects including steroid diabetes, increased blood pressure, oedema, acne and hirsutism in the intervention groups.142 A...

Tuberculous Osteomyelitis

X-rays may remain negative for weeks and thus are not helpful in the early stage of the disease. Later on the vertebral body may show osteopenia, osteolysis, and sclerosis. The endplate may be eroded and the disc space reduced. These radiological changes do not differentiate TB spondylitis from other infections. In later stages of the disease there may be total vertebral body collapse with fusion across the disc space due to reactive new bone formation. A kyphotic deformity gibbus may be formed. When two adjacent vertebral bodies are affected, the intervertebral disc may be deprived of its nutrition and tend to lose its height (Figures 6-8 and 6-9). Calcifications in the para-vertebral soft tissues are typical of this disease.

[3 Site Specific Fluorescent Labeling of Estrogen Receptors and Structure Activity Relationships of Ligands in Terms of

The estrogen receptor (ER) is a ligand-regulated transcription factor that belongs to the nuclear receptor (NR) superfamily and acts as a dimeric species. There are two subtypes of ER, ERa and ERb, which are both mainly regulated by the endogenous estrogen, estradiol (E2). ER modulation is involved in the development and regulation of reproductive, cardiovascular, and bone health, in addition to controlling various aspects of cognitive function.1 In addition to maintaining homeostasis in many tissues, an excessive activity of ER has been correlated with the development and proliferation of certain breast and uterine carcinomas.2 In clinical settings, ER activity is modulated with exogenous estrogen and antiestrogen ligands as hormone replacement therapy (HRT) and as anticancer agents.3

Ankylosing Spondylitis

Over time, enthesopathic changes appear and may, eventually, result in spine fusion. The fusion is caused by ossification of the anterior, posterior, and interspinous ligaments the facet joints and the discs. The spine ends up as a very rigid, solid structure known as bamboo spine (Figure 8-1). Lack of spinal motion interferes with the ability of the spine to withstand flexion and extension moments and brings about spinal osteoporosis. The spine becomes very fragile and as a result even simple, noncomplicated falls may lead to an unstable spinal fracture. In many instances the fracture occurs through the calcified discs (Figure 82). Because of this fragility, new-onset spinal pain should never be taken lightly in patients with AS. If X-rays of the painful region fail to detect an apparent fracture, bone scan and thin-slice CT or multislice CT with the multiplanar reconstructions may help reveal it at an early phase. Spine fractures are more common in the thoracic segments but may...

Insulinlike growth factor biological effects

IGFs also play a core role in tissue renewal and repair (e.g. wound healing) during adulthood. For example, these growth factors play a central role in bone remodelling (i.e. reabsorption and rebuilding, which helps keep bones strong and contributes to whole-body calcium homeostasis). Reabsorption of calcified bone is undertaken by osteoclasts, cells of haemopoietic origin whose formation is stimulated by IGFs. These mitogens may, therefore, influence the development of osteoporosis, a prevalent condition (especially amongst the elderly), which is characterized by brittle, uncalcified bone.

Patient Admissibility Contraindications and Training 1631 Patient Admissibility Criteria

No recent history of long bone stress fractures, osteoporosis, or severe hip or knee joint disease a bone density test is advisable in cases of women over 40 years or patients who are many years (10 or more) beyond date of injury (the author had a patient 40 years postinjury who had no problem and was accepted to the FES ambulation program)

Differential impact of different types of screening

People's perceptions of the condition being screened for are likely to be important. For example, screening for conditions which are regarded as being possibly fatal and or incurable (e.g. cancer, AIDS) appears to evoke more negative reactions than screening for what are perceived to be a less serious condition that can be prevented (e.g. osteoporosis). People often perceive AIDS as being associated with social stigma which may add to the burden of a positive HIV test result.

Historical Perspectives On Carbohydrate

Since 1980, dietary recommendations for people with diabetes have unanimously emphasised reducing saturated fat intake. However, if saturated fat intake is reduced, the energy has to be replaced by some other nutrient. Because there are concerns about potential adverse effects of high-protein diets on renal and bone health, the choice is either more carbohydrate or more unsaturated fat. And here lies the controversy. Since carbohydrate is the main glycaemic element in the diet (being the main precursor of blood glucose), an increase in dietary carbohydrate might be expected to result in greater postprandial glycaemia and compromise diabetes control. An increase in fat, on the other hand, might promote weight gain and decrease insulin sensitivity.

Benefit of a Gluten Free Diet

Although general clinical experience and the literature suggest that most adult celiacs are not highly compliant with a gluten-free diet, most patients are symptom free in spite of continued gluten ingestion. As discussed above there is some evidence that the incidence of malignancy is reduced in celiac patients and those with DH who adhere to a gluten-free diet. Other benefits of a gluten-free diet include improvement of body size and composition, iron deficiency 52 and osteopenia. There is also the suggestion from some studies that a gluten-free diet may delay or prevent the development of other autoimmune disorders, although this is not supported by other reports 78 . The question of how much gluten is safe remains unanswered. In the absence of data to support specific recommendations, patients should be encouraged to stay free of dietary gluten wherever possible in order to induce and maintain remission and potentially prevent complications of the disease.

Posttransplant Malignancies

Renal transplantation is associated with several functional and structural abnormalities of the skeletal system. Some of these complications such as persistent hyperparathyroidism, aluminum-associated bone disease, B-2 microglobulin amyloidosis may be preexistent at the time of transplantation. Subsequent development of osteopenia, osteonecrosis and gout may cause additional skeletal problems. The most common posttransplant skeletal disorders are immunosuppression related bone disease, painful leg syndrome and avascular bone necrosis. Osteoporosis is prevalent after renal transplantation and is characterized by decreased bone mineral density BMD , fractures and skeletal pain. The most significant bone loss is noted during the early posttransplant period when corticosteroid dosage is high and seems to correlate directly with total amount of corticosteroid used. Additionally cyclosporine and persistent elevation of parathyroid hormone levels may exacerbate the bone loss after...

Lactation Introduction

Breast milk is widely acknowledged to be the most complete form of nutrition for infants. Breastfeeding poses multiple benefits for infants including health, growth, immunity, and development. Specific infant benefits of breastfeeding include decreased episodes of diarrhea, respiratory infections, and ear infections. Breastfeeding poses multiple maternal benefits as well, including a reduction in postpartum bleeding, earlier return to prepregnancy weight, reduced risk of premenopausal breast cancer, and reduced risk of osteoporosis 34 . In order to encourage breastfeeding, the Health and Human Services Healthy People 2010 initiative targets increasing the percentage of mothers who breastfeed to 75 in the early postpartum period, 50 at six months, and 15 at one year 35 . Professional medical organizations encourage breastfeeding as well 36, 37 . The American Academy of Pediatrics (AAP) considers breastfeeding to be

Ovulation suppression

Ovarian suppression with GnRH agonists induces menopause. PMS symptoms will be relieved, but patients experience menopausal side effects, including irritability, insomnia, hot flashes, and vaginal dryness. To prevent osteoporosis, add-back therapy with estrogen and progesterone is required.

Risk of Collapse of Adjacent Vertebrae After Vertebroplasty

In a series of 177 osteoporotic patients treated with vertebroplasty and reviewed retrospectively after two years or more, 22 (12.4 ) developed a total of 36 new vertebral body fractures (26). In another small series of 25 patients with osteoporosis who had a total of 34 levels treated with vertebroplasty, 13 (52 ) developed at least one new vertebral fracture at an average follow-up of 48 months (range 12-84 months) (27). However, these figures should be compared to the natural history of osteoporotic VC. Lindsay et al. evaluated the risk of new vertebral fractures within one year following a vertebral fracture in patients with osteoporosis enrolled in four large three-year prospective clinical trials (28) they found an incidence of 19.2 new vertebral fractures in the year following the fracture (21). Therefore, there is no evidence that the overall incidence of new vertebral fractures is increased following vertebroplasty.

Management of hypothalamic dysfunction

Hypoestrogenic women are at risk for osteoporosis and cardiovascular disease. Oral contraceptives are appropriate in young women. Women not desiring contraception should take estrogen, 0.625 mg, with medroxyprogesterone (Provera) 2.5 mg, every day of the month. Calcium and vitamin D supplementation are also recommended.

Introduction role of dietary and supplementary calcium in weight control

The recommended daily intake of calcium (1000 mg day for most adults, 1200 mg day for pregnant women) has been set to meet the requirements of bone-health and the prevention of osteoporosis. Beyond this, calcium plays an essential role in numerous other vital functions regulation of cell membrane fluidity and permeability, nerve conduction, muscle contraction and blood clotting. Calcium has anti-hypertensive properties and the consumption of calcium in sufficient amounts may reduce the risk of colon cancer. Various studies over the last few years have shown that increased calcium intake can significantly fight overweight and obesity.

Therapeutic options

Hormone replacement therapy should be considered to relieve vasomotor symptoms, genital urinary tract atrophy, mood and cognitive disturbances, and to prevent osteoporosis and cardiovascular disease. It also may be considered to help prevent colon cancer, Alzheimer's disease, and adult tooth loss. C. Effective doses of estrogen for the prevention of osteoporosis are 0.625 mg of conjugated estrogen, 0.5 mg of micronized estradiol, and 0.3 mg of esterified estrogen.

Prevention and treatment strategies

Females who are not willing or incapable of receiving estrogen therapy and have osteopenic bone densities may consider alternative agents such as alendronate and raloxifene. After the age of 65, a bone density test should be performed to decide if pharmacologic therapy should be considered to prevent or treat osteoporosis. Calcium alone may not prevent osteoporosis

Conclusions and future trends

On the other hand, it seems quite justified to develop low-calorie foods for the purpose of maintaining weight reduction, and to fortify them with functional food components with weight reducing properties, where calcium can also provide a relevant contribution to health. Alongside this, the desirability of a plentiful calcium supply from milk products, other (fortified) foods and calcium supplements remains without question, particularly for osteoporosis prevention, but also for its potential cancer-preventive effects and its favourable effect on blood pressure.

Bisphosphonatesalendronate Fosamax

Alendronate is an oral bisphosphonate approved for the treatment and prevention of osteoporosis. Alendronate exerts its effect on bone by inhibiting osteoclasts. 2. The dose for prevention of osteoporosis is 5 mg per day. This dose results in significant increases in densities of 2-3.5 , similar to those observed in ERT. The dose for treatment of osteoporosis is 10 mg per day. Alendronate provides an approximate 50 reduction in fracture risk at both skeletal sites.

Sources of further information and advice

Almustafa m, doyle f h, gutteridge d h, hand d j, davis t m, spinks t j, freemantle c and joplin g f (1992), 'Effects of treatments by calcium and sex hormones on vertebral fracturing in osteoporosis', Q. J. Med., 83, 283-294. azadbakht l, mirmiran p, esmaillzadeh a and azizi f (2005), 'Dairy consumption is inversely associated with the prevalence of the metabolic syndrome in Tehranian adults', Am. J. Clin. Nutr., 82, 523-530. barger-lux m j, davies k m, heaney r p, chin b k and rafferty k (2001), 'Calcium supplementation may attenuate accumulation of fat in young women', J. Bone Miner. Res., 16, S219. barr s i (2004), 'Calcium and obesity', in Mela D. (Ed.), 'Food, Diet and Obesity', substances on fecal fat', Gastroenterology, 41, 242-244. EDELSTEIN s (2004), 'Calcium citrate and bone health', in Remacle, C. and Reusens B. (Eds), 'Functional Foods, Ageing and Degenerative Disease', Cambridge, Woodhead, pp. 174-183. flynn a and cashman k (1999), 'Calcium', in Hurrel, R. (Ed.), 'The...

Hormonal Influences on the Pelvic Floor

Reproductive hormones, especially estrogen, have a significant impact on pelvic floor function. Hormonal changes that occur during a woman's lifespan impact many aspects of female physiology. With the onset of menopause, it becomes evident that estrogen sensitivity is greatest in the central nervous system and the genital tissues. The most frequently occurring initial symptoms of estrogen deprivation include hot flushes, mood changes, and emotional irritability. These central nervous system symptoms are promptly reversible with systemic estrogen replacement. More prolonged duration of estrogen deprivation will lead to other known consequences such as osteoporosis and urogenital atrophy. It is estimated that 80 of postmenopausal women have hot flushes, and that not all women will develop osteoporosis. However, urogenital atrophy occurs universally. Interestingly, many women with urogenital atrophy are asymptomatic.1 Many treatments are currently available for prevention of and therapy...

Preventing and Rehabilitating Hip Fractures Thesis Submitted to the Rehabilitation Board of HKCOS Bone Mineral Density 591 19.7.4 Osteoporosis Risk 594 This thesis discusses a new comprehensive programme for tackling both the rehabilitation and prevention of geriatric hip fractures patients based on the latest evidence and studies of the author as well as those of numerous researchers in different disciplines. In the author's opinion, any hip fracture programme that does not incorporate secondary prevention of falls and management of osteoporosis is doomed to fail in the long run Despite marked advances in surgical techniques, technology and anaesthesia, which all serve to improve the rates of survival and successful outcome for elderly people with hip fractures, it is common knowledge that not less than 50 of these hip fracture patients fail to achieve physical, emotional or social recovery back to baseline, with a significant number becoming unable to return home or function independently, even after operation (Magaziner et al., J Gerontol Med Sci 1990). Moreover, many...

Conditions Accompanied by Neuropathic Pain

Stage 1 consists of pain, the affected extremity being either warm or cold, along with accelerated nail and hair growth. The symptoms come on at any time, from hours to weeks after the original injury. Stage 2 (the dystrophic phase) consists of continuing pain in the affected limb, which is cold and cyanotic. Nails become rigid and brittle and osteoporosis develops. Finally, lack of use of the affected limb leads to

Fund Conduct African American Only Research

Congress took that approach in the 1993 NIH Reauthorization Act when it also created an Office of Women's Health and an Office of Minority Health Care. The Women's Health Initiative and Office of Women's Health resulted from a recognition that different factors may affect the health of women and men, that women have been excluded from much past clinical research, and that if their health needs are to be met, special attention to research on women is needed, for example, of the effects of estrogen replacement therapy on osteoporosis. This program does not constitute impermissible gender discrimination because men are not being denied research into diseases that they uniquely have, for example, prostate cancer. The purpose is to meet the health needs of a large group of the population that would otherwise go unmet.

Kyphoplasty Percutaneous And Open

Osteoporosis Kyphoplasty is rapidly becoming an important therapeutic option for neurosurgeons treating vertebral compression fractures from osteoporosis and metastatic disease. Kyphoplasty's effectiveness for reducing pain, restoring vertebral body height, and on the improving functional outcome in patients warrant its practice by neurosurgeons. Future refinements will undoubtedly include clarification of the ideal time to perform kyphoplasty after a fracture, as well as the use of select bone substitutes rather than PMMA. Furthermore, bio-mechanical studies will help us to understand the effects of kyphoplasty on surrounding structures and could complement our existing knowledge of vertebroplasty mechanics. Lastly, we await data on the long-term efficacy of percutaneously fixed and restored vertebral bodies.

Cardiovascular Complications

Estrogen replacement therapy is associated with an increased risk of thromboembolic disease, and alternative therapies for osteoporosis and cardiovascular protection are recommended for individuals with prior throm-boembolic episodes. The problems generally are more severe and or more frequent when either of the synthetic estrogens, ethinyl estradiol or mestranol, is used. These preparations alter liver function more significantly than do the natural estrogens, such as the sulfate conjugates or esterified estrogens. Alterations in the synthesis of specific liver proteins, such as coagulation factors and fibrinogen, are implicated in the formation of thromboembolisms. Conjugated estrogens, tamox-ifen, clomiphene and raloxifene also increase the frequency of thromboembolic disease.

Polymorphisms Affecting Drug Receptors And Targets

Polymorphisms affecting steroid hormone nuclear receptors may affect individual response to drugs and hormones. For example, glucocorticoid resistance in asthma patients has been associated with increased expression of the glucocorticoid receptor -isoform (Sousa et al., 2000) activating mutations of the mineralocorticoid receptor have been linked to hypertension exacerbated by pregnancy (Geller et al., 2000) and dominant negative mutations of peroxisome proliferator-activated receptor gamma (PPAR gamma) have been associated with severe insulin resistance, diabetes mellitus and hypertension (Barosso et al., 1999). Huizenga et al. (1998) identified a polymorphism affecting the glucocorticoid receptor that was present in 6 of their elderly study population. These individuals appeared healthy, but exhibited increased sensitivity (reflected in cortisol suppression and insulin response) to exogenously administered glucocorticoids. The authors postulated that this increased lifelong...

Statins Can Cholesterol Metabolism Modify the Pathophysiology of AD

Statins are among the most successful medications available in the pharmaceutical formulary. Statins are extraordinarily important tools for reducing morbidity due to cardiovascular disease, such as myocardial infarction and transient ischemic attacks (Shepherd et al., 2002). Statins have also been shown to reduce osteoporosis (Rejnmark et al., 2002). Statins might also reduce inflammation (Marz & Koenig, 2003). Their relative safety combined with putative efficacy makes them a very appealing prospect for therapy of AD.

Multipurpose Databases

Failure of clarity at this stage could doom the study from the onset. Investigators interested in a particular hypothesis can often be mesmerised by the apparent abundance of information available to them. They should keep in mind that it is crucial to restrict themselves to appropriate comparisons. Thus if one is looking at the effect of, say, hormone replacement therapy on osteoporosis, the relevant outcome measure available in such databases is generally a fracture. However, not all fractures are relevant. Indeed, most are irrelevant to the hypothesis, as they will have an obvious and sufficient cause, such as a road traffic or other accident, an underlying neoplasm or pre-existing bone disease. Similarly, not all exposures to hormones are relevant. For example, it would seem unlikely (biologically implausible) that a single prescription for such treatment would be relevant to the outcome of interest. Trained epidemiologists are used to thinking of chance, bias and confounding as...

Monitoring of Distraction in Hypertrophic Nonunions

Some Authors have reported the use of additional methods of monitoring new bone formation during distraction. Mazess 32 , Eyres et al. 33 , and Reiter et al. 34 described a quantitative assessment of bone mineralization during the distraction procedure using dual photon or dual energy x-ray absorption, based on the measurement of the bone mineral density in the newly formed bone and in the adjacent bone. These studies provided a precise assessment of the mineralization, which is closely related to the stiffness, torsion, and stability of bone.

The Molecular Endocrinology Of Diabetes Mellitus

Wolcott-Rallison syndrome (OMIM 226980) is an autosomal recessive disorder characterized by neonatal-onset diabetes in association with multiple epiphyseal dysplasia, decreased growth, osteoporosis, and renal insufficiency. The causative gene has been identified as eukaryotic translation initiation factor 2-a kinase 3 (EIF2AK3) (OMIM 604032) (123). This kinase is thought to play a role in regulating protein flux through the endoplasmic reticulum (ER), in particular in coupling the rate of insulin synthesis with the capacity for peptide processing in the ER (124).

Too Much Bone The Middle Ear in Sclerosing Bone Dysplasias


The middle ear changes in Sclerosteosis and Van Buchem disease are described. Reduced bone resorption occurs due to faulty activity of the sclerostin molecule, a product of the recently discovered SOST gene in chromosome 17. Syndactyly draws attention to sclero-teosis, and a conductive hearing loss develops before age six in both conditions. Acute, repeated attacks of facial palsy, similar to Bell's palsy, are usually the first symptoms in both conditions. Total facial nerve decompression can stop the attacks of facial paralysis. The hearing loss is a problem because new bone formation continues up to age 21. Life saving craniectomy becomes necessary when increased intracranial pressure develops, and this may have to repeated. The sclerostin molecule is now of major interest to the researchers who want to develop a treatment for osteoporosis. The SOST gene, which is involved in sclerosteosis and Van Buchem disease, was discovered a few years ago on chromosome 17. Bone metabolism...

Synthetic Agents Acting Via Estrogen And Progesterone Receptors

Raloxifene (Evista) is a new SERM approved for use in the treatment and prevention of osteoporosis because it has estrogenic activity in bone. Raloxifene is an estrogen antagonist in both breast and endometrial tissues. The estrogenlike properties of raloxifene result in the maintenance of a favorable serum lipid profile (decreased low-density lipoprotein levels with no change in either high-density lipoproteins or triglycerides). Raloxifene is 95 bound to plasma proteins. Absorption of raloxifene is impaired by cholestyramine.

Venous thromboembolism

Low-molecular-weight heparin does not cross the placenta. Limited experience with this agent has been gained during pregnancy, but its use is attractive because its longer half-life allows a once-daily regimen and because it lowers the risk of heparin-induced osteoporosis and thrombocytopenia.

Hormone Replacement Therapy

The four most common symptoms associated with menopause are vasomotor disorders, or hot flashes urogenital atrophy osteoporosis and psychological disturbances. A varying proportion of women may have one or more of these symptoms. Osteoporosis One in four postmenopausal women have osteoporosis. Osteoporosis, a decrease in bone mass, constitutes the most serious effect of menopause. It has been estimated that following cessation of ovarian function, the loss of bone mass proceeds at a rate of 2 to 5 per year. As a result of osteoporosis, as many as 50 of women develop spinal compression fractures by age 75, and 20 will have hip fractures by age 90. Estrogen replacement therapy can prevent bone loss and actually increase bone density in postmenopausal women. Estrogen treatment is the most effective therapy for osteoporosis and significantly reduces the incidence of bone fractures in postmenopausal women. The usual dose of estrogen prescribed is 0.625 mg day of conjugated equine estrogens...

Using calcium in functional food products

Generally, functional foods are neither dietetic products nor food supplements, but processed foods with distinctive added-value features such as health and well-being. In order to be able to differentiate themselves from the established products, food companies use specific health claims, among which the link between calcium and bone health is one of the most widely used and accepted claims worldwide. According to Leatherhead Food International (2005), the functional foods market in the five major European markets, the United States, Japan and Australia had a combined turnover of US 9.9 billion in 2003. Leatherhead uses a strict definition, measuring only products that make genuine functional health claims. By country, this can be broken down as follows Japan, 45.3 United States, 26.9 France, 7.2 UK, 7.1 Spain, 5.5 Germany, 4.9 Italy, 1.9 Australia, 1.2 . Total sales are expected to increase by 16 per annum over the next 5 years to reach US 21 billion by 2008, with Japan accounting...

Reproductive and Developmental Toxicology Carole A Kimmel PhD Judy Buelke Sam

Implantation Embryonic Development

Agents that interfere with the development of the reproductive system and the normal hormonal patterns necessary to regulate development may alter the intricate processes involved in a number of different ways. For example, the normal structure of the ovaries, uterus, oviducts, cervix, and vagina can be altered during development, resulting in interference with fertility and pregnancy. This was the case with the drug diethylstilbestrol (DES), a potent synthetic estrogen used in the 1950s and 1960s to prevent spontaneous abortion. Unfortunately, the drug was not effective in preventing labor but had profound effects on the development of the reproductive system in both boys and girls exposed before birth and produced a rare form of cancer (vaginal adenocarcinoma) in females not detected until after puberty (28). Synthetic androgens and antiandrogens also alter the structure of reproductive organs by interfering with the normal hormonal milieu during development. For example, ethinyl...

Animal Models Of Depression

Another way to validate or reject hypotheses regarding the biochemical or molecular mechanisms underlying depression is to alter the expression of genes related to stress reactions, namely the monoamine- and the HPA system28. In looking at the HPA axis the glucocorticoid receptors (GRs) are central in the feedback loop29. Mice with a general genetic downregulation of GRs (GR-heterozygote) show significantly increased helplessness30. Furthermore, these animals have a pathological DEX CRH test (nonsuppression), similar to severely depressed patients. In line with these findings, mice that overexpress GRs via a yeast artificial chromosome (YGR mice) resulting in a twofold gene dose elevation are stress-resistant with reduced helplessness, and are oversuppressors in the DEX CRH test. An interesting phenotype is also observed in mice with a brain-specific knockout of the GRs. In terms of the endocrine system these animals show a disinhibition of the HPA system with hypercortisolemia very...

Supplemental Reading

Treatment of postmenopausal osteoporosis. N Engl J Med 1998 338 736-746. Neer RM et al. Effect of parathyroid hormone (1-34) on fractures and bone mineral density in post-menopausal women with osteoporosis. N Engl J Med 2001 344 1434-1441. Plotkin H et al. Dissociation of bone formation from resorption during two-week treatment with PTHrP (1-36) in humans Potential anabolic therapy for osteoporosis. J Clin Endocrinol Metab 1998 83 2786-2791.

Complications and comorbidities

Older patients with long-standing alcoholism are at high risk for development or aggravation of many medical problems, especially liver disease, several cancers, disorders of glucose, fat and uric acid metabolism, osteoporosis, anaemias, congestive heart failure, aspiration pneumonia, and accidental injuries. (7) Control of hypertension and diabetes mellitus is compromised by heavy drinking. Acute doses of alcohol compete with many medications (e.g. warfarin, phenytoin, most benzodiazepines, propanolol) for hepatic drug metabolizing enzymes in the cytochrome P-450 system, which can produce higher than desired drug blood levels, while chronic alcohol dosing induces the cytochrome P-450 system and can lead to more rapid metabolism of the same medications, with resulting lower than desired drug blood levels.(8) Inhibition of hepatic alcohol dehydrogenase by such drugs as chlorpromazine and isoniazid, or inhibition of gastric alcohol dehydrogenase by histamine receptor antagonists (e.g....

Phytochemicals As Nutraceuticals

The oligosaccharides are fermented by colonic microflora in the large intestine, a bifidogenic effect, and they are called prebiotics. Organic acids are produced (lactate, proprionate, butyrate, and acetate) by the fermentation process, and two distinct effects are observed (1) the local intestinal pH is lowered, which dissolves calcium-phosphate-magnesium complexes that have been formed during transit through the small intestine and (2) intestinal concentration of ionized minerals is raised. Interestingly, improved absorption also leads to improved bone mineralization and an increased resistance against bone fracture and osteoporosis. Prebiotics induce the reduction of growth of harmful bacteria such as E. coli and Clostridium. Thus, the severity and incidence of diarrhea are diminished in addition, relief of constipation and reduction of putrefactive substances in the colon have been observed.41,42

Diagnosis And Management Of Depression In Older People

Due to changes in metabolism in older people, there is an increased risk of toxicity from antidepressants, especially tricyclic antidepressants (TCAs), and that makes this class of drugs less tolerable. However, even newer types of antidepressants, such as the selective serotonin reuptake inhibitors (SSRIs), can cause water retention (the consequences include headaches, lethargy and, in more severe cases, confusion), weight loss and balance problems (Nelson, 2001). Balance problems are potentially very difficult to tolerate in older people, especially for older women, who, due to osteoporosis, are at increased risk of hip fractures after falls. Mittmann et al. (1997) noted that, although it is commonly stated that older adults tolerate SSRIs better than TCAs, their meta-analysis of the safety and tolerability of antidepressants suggested there were no differences in the rates of adverse events with the different classes of antidepressants. Interestingly, Mittmann et al. (1997) also...

Nutrition as primary therapy in ibd

Disease, Ludvigsson et al. reported equivalent clinical response rates with elemental and polymeric feedings, but greater weight gain with the polymeric formula 64 . They attributed this to the greater intake of formula with the polymeric formula, hypothesizing that since part of their patients drank the formula, the flavor of the feeding was more acceptable to that group. However, even after adjustments for caloric intake, the difference in weight gain persisted. Knight and colleagues recently published a retrospective study of 44 pediatric patients who were newly diagnosed with Crohn's disease and elected to use enteral nutrition in lieu of steroids and other medications 65 . In these patients median time to remission was 6 weeks, 25 of 40 relapsed with a mean duration of remission of 54.4 weeks and time to first steroid use of 68 weeks for the 23 who eventually required steroids. The avoidance of steroids in children is particularly important with respect to growth and bone health....

Can Starving Yourself Affect Rate Of Healing Of Surgery Wounds

A deficiency of vitamin D results in inadequate intestinal absorption and renal reabsorption of calcium and phosphorus. As a consequence, serum calcium and phosphate concentrations drop, and serum alkaline phosphatase activity increases. In response to low serum calcium levels, hyperparathyroidism may occur. Vitamin D deficiency has been associated with adverse effects on the skeletal (50,79-87), neuromuscular (88,89), endocrine (47,90,91), and immune (58-61,92-94) systems. Clinical symptoms include growth arrest in children, low bone mineral density, increased fracture incidence, and impaired healing. Those presenting with a heightened risk of hypovitaminosis D (Table 9.1) merit assessment of vitamin D status with therapeutic correction of low serum levels in an effort to minimize the adverse effects of classic deficiency symptoms (delayed growth and osteoporosis) as well as to address more recent findings demonstrating benefits of vitamin D as it pertains to the immune system and...

Testicle Shrinkage Treatment

Very Small Testicular Size

If you are approaching menopause, discuss your options for hormone replacement therapy (HRT). Menopausal symptoms, your potential for developing osteoporosis, and your risk for developing cardiovascular disease should be part of this discussion.

Adverse Effects and Contraindications

Side effects depend on the route, dose, and frequency of administration, as well as the specific agent used. Side effects are much more prevalent with systemic administration than with inhalant administration. The potential consequences of systemic administration of the corti-costeroids include adrenal suppression, cushingoid changes, growth retardation, cataracts, osteoporosis, CNS effects and behavioral disturbances, and increased susceptibility to infection. The severity of all of these side effects can be reduced markedly by alternate-day therapy.

Treatment Of Giant Cell Myocarditis

The risks of aggressive immunosuppression in this setting are considerable. Cyclosporine can cause renal insufficiency, hypertension, liver function abnormalities, hir-sutism, and gum enlargement. Muromonab-CD3 can cause profound hypotension, fever, chills, diarrhea, nausea, and vomiting. Long-term use of prednisone can cause osteoporosis and fractures, myopathy, cataracts, and glaucoma. Therefore, these drugs should be used to treat giant cell myocarditis by individuals experienced in their use at specialized centers.

PTH in Target Tissues

PTH has two levels of action in bone. First, in response to acute decreases in serum calcium, PTH stimulates surface osteocytes to increase the outward flux of calcium ion from bone to rapidly restore serum calcium. Thus, during brief periods of hypocalcemia, PTH release results in mobilization of calcium from labile areas of bone that lie adjacent to osteoclasts. This effect is not associated with any significant increase in plasma phosphate or bone resorption. Second, PTH induces transformation of osteoprogenitor cells into osteoclasts, which increase bone formation. Thus, PTH has anabolic action on bone formation at physiological levels, and it is this action that allows it to be used pharmacologically to treat osteoporosis. However, in conditions that result in chronic calcium deficiency or prolonged hypocalcemia (e.g., renal osteodystrophy, vitamin D deficiency, or malabsorption syndromes), PTH mobilizes deep os-teocytes in perilacunar bone and can result in significant bone...

Genetic Variation in the Inflammatory Response

Inflammation drives the development or severity of a large number of diseases (e.g., atherosclerosis, asthma, ulcerative colitis, postmenopausal osteoporosis, sleep disorders). Variation in genes that encode proteins regulating inflammation may underlie a large proportion of interindividual variation in susceptibility to numerous diseases. Furthermore, variation in the production or function of cytokines can cause variation in inflammatory responses that in turn influences the progression of inflammatory disease.

Early adolescent gender identity disorder

The gonadotrophin hormone-releasing hormone agonists that block the release of gonadotrophins and gonadal hormones put puberty on hold. Although there is concern that more than a year, perhaps two, of gonadal steroid suppression may predispose to osteoporosis, this concern is, at this time, more theoretical than empirically based.

Prevalence of Malnutrition

The lowest quartile of BCM were diagnosed as malnourished by SGA. BCM was correlated (although not strongly) with arm-muscle circumference (r 0.55) and midarm muscle circumference (r 0.48). None of the serum laboratory values (bilirubin, prothrombin time, albumin, total lymphocyte count, micronutrient levels, lipid concentrations, amino acid concentrations) were correlated with BCM. Parameters in which the lowest quartile correlated with low BCM included serum blood levels of urea nitrogen (p 0.002) and creatinine (p 0.01), HG (p 0.001), bone mineral density (p 0.001) and lean body mass by DXA (p 0.001). When multiple logistic regression was applied to all of the assessment variables, arm-muscle circumference and HG had the greatest influence on BCM. The authors concluded that HG and arm-muscle circumference were the most sensitive markers in diagnosing BCM loss in the liver disease patient.

Growth hormone deficiency

Growth hormone deficiency is probably the most common endocrine expression of hypopituitarism. Acquired growth hormone deficiency in adulthood results in reduced muscle strength and exercise capacity, reduced thermoregulation and sweating ability, subnormal kidney function, decreased lean body mass and bone mineral density, abnormal thyroid hormone, lipid, and carbohydrate metabolism, myocardial dysfunction, and impaired social well being, and it leads to increased mortality due to cardiovascular disease ( 1995). Growth hormone replacement therapy in growth-hormone-deficient adults improves these symptoms.

Soy and Other Phytoestrogens

It is believed that the lower risk of breast cancer, cardiovascular disease, and osteoporosis in Asian women is partly due to their high soy diet, since these benefits are lost when they adopt Western dietary habits. Flaxseed, from flax (Linum usitatissimum), is the source of another type of phytoestrogen, lignan, as well as linolenic acid and omega-3 fatty acids. Red clover (Trifolium pratense) contains isoflavones as well as coumarin and produces effects somewhat similar to those of diethylstilbestrol. The negative effect of red clover on sheep fertility threatened the economy in New Zealand at one time.

Minerals a maze of confusion

Eral element) doesn't come from a rock, it can still eventually deposit abnormally in your tissues if you take too much. There is a lot of calcium in most diets, and even a relatively small amount of calcium supplementation taken on a regular basis can result in undesirable, rocklike, nonbiologic deposits of calcium in the tissues. These calcium deposits will promote and accelerate almost all of the many different degenerative diseases seen with increasing age. Short-term calcium supplementation to support bone healing and healing in general is about the only reasonable way to supplement this mineral element. Toxicity and poor nutrition are the primary causes of osteoporosis, and these factors must first be addressed if osteoporosis is to be controlled. Causing other diseases with indiscriminate calcium supplementation is not the answer to trying to protect yourself from osteoporosis. One of the best examples of this toxic accumulation is seen with the most common forms of calcium...

Prospects for Use of Pharmacogenomics in the Pharmaceutical Industry

Meanwhile, the companies are deeply concerned that the cost of drug development, regulatory approvals, and marketing will be nearly as great for new drugs that are much more narrowly targeted and, therefore, have much smaller markets. Companies have been reluctant to market existing drugs to restricted populations that can be defined with biomarker tests, as in the case of bisphosphonates for osteoporosis patients, which were marketed to all postmenopausal women, rather than to the 50 of such women who have evidence of predisposition to, or early manifestations of, osteoporosis by bone density measurement and or N-terminal collagen cyclic peptide biomarkers (Osteomark) (Miller et al., 1999). The possibility that a drug will be effective in an individual patient, even if the likelihood is very low, may not preclude companies from marketing the drug and physicians from using it, especially if there are few other effective alternatives. Probably the drug will be aggressively marketed...

Growth and Development

Bone remodeling occurs throughout adult life. Osteoblasts are the bone cells that are responsible for increasing bone mass. Bone loss occurs through the activity of other bone cells, called osteoclasts. Normal bone remodeling takes place when there is a balance between osteoblast and osteoclast activities. Estrogens maintain bone mass by inhibiting bone resorption by the osteoclasts. Estrogens inhibit the production of cy-tokines by peripheral blood cells and the osteoblasts that stimulate osteoclast activity. In postmenopausal women, declining estrogen levels give rise to a net increase in osteoclast activity and loss of bone mass resulting in the serious condition osteoporosis. Also, progestins antagonize loss of bone.

Clinical approach when the risk to fall is low and mobility is well preserved

Another aspect of delaying potential consequences of PD is the early detection and aggressive treatment of osteoporosis. Osteoporotic bone is significantly more vulnerable to injury, and even minor trauma can sometimes cause fractures that require surgery and lead to loss of mobility. All PD patients in all stages of the disease should be educated to assess their bone density regularly throughout the course of the disease and follow professional advice how to protect or treat osteoporosis.

The Primary Care Physician as a Member of the Bariatric Team

Patients need to understand that surgery changes the stomach but does not change the mind. Eating behaviors, attitude towards food, perceptions as to how much food should be eaten at one setting must change. Bariatric surgery does not provide the patient with an automatic long-term weight reduction guarantee. Even after dramatic weight loss, weight regain through engaging in old eating behaviors can occur if emotional, mental, and social issues are not addressed before and after surgery. At present, psychologists, dieticians, and the surgeon address the patient's mental, emotional, and medical needs. As a member of the bariatric team, the primary care physician can continue this care indefinitely because of the long-term relationship with the patient. For instance, patients who have had bariatric surgery, especially those with restrictive-malabsorptive procedures, have special medical needs for the rest of their lives. Patients must be vigilant in preventing iron deficiencies, B12...

Information Collection

The collection of a targeted medical history of the proband serves two purposes (1) the identification of premalignant conditions associated with subsequent cancer progression and (2) the estimation of other risk factors that may interact with or modify familial cancer risk. A careful reproductive history is pertinent to a number of common cancers in women. Exogenous hormone use and other medication history is also of value. The knowledge of other medical conditions may affect the management recommendations for reducing cancer risk. Caution about the use of exogenous estrogens in women with a familial predisposition of breast cancer, for example, may be tempered by a strong personal or family history of osteoporosis.

Correcting deficiencies

Unless the physician has particular expertise in nutrition and time to adequately address these issues, the assistance of a dietitian can be useful in identifying nutrient deficits, indicating which dietary practices may contribute and correcting them, motivating patients to comply with recommendations and monitoring the patient. Inadequate caloric and protein intakes require an understanding of the limitations in specific patients in order to develop effective and sometimes creative approaches to correction with the diet itself, as well as the use of caloric supplements and specific therapies. Availability of a chewable multivitamin containing water soluble forms of the fat soluble vitamins will frequently help in those with specific deficits of vitamins A, D, E and K. However, achieving 25-OH vitamin D levels deemed necessary to treat osteoporosis usually requires very high doses (50,000 international units several times weekly) of ergocalciferol. When such high doses are used, it...


Absorption of B12 depends on the presence in the stomach of the intrinsic factor, a mucoprotein enzyme. Autoimmune reactions in the body may either bind the intrinsic factor to prevent B12 absorption or prevent cellular ability to produce the enzyme. B12 is closely related to the activity of four amino acids, pantothenic acid, and vitamin C. It also helps iron function better in the body and aids folic acid in the synthesis of choline. It has a role in the production of DNA and RNA, which are the body's genetic material, and in s-adenosyl-L-methionine (SAMe), a mood altering substance. The vitamin, along with folic acid, regulates homocysteine levels. Homocysteine is an amino acid which, in excess, is associated with heart disease, stroke, osteoporosis, and Alzheimer's disease. levels, an amino acid associated with risk of heart disease, strokes, osteoporosis, and Alzheimer's disease. It is necessary for the production of the mood related substance SAMe.

Plain Radiography

The earliest alterations can be observed on radiographic images only some weeks after the septic process has started and consist of a radiotrans-parency area in relation to osteopenia, sometimes followed by a nonspecific periosteal reaction. In fact, the bone alterations depend on the inflammatory state during the early stages (with hyperemia and osteopenia) rather than on the bone tissue damage. In later phases, an impoverishment of bone matrix is clear, and the possible presence of sequestration can be detected.

ACTHproducing Tumors

This can be due to lesions of the adrenal cortex, to extrapituitary, ectopic production of ACTH by neoplasms, to excessive corticotrophin-releasing hormone (CRH) production, and to pituitary-dependent ACTH excess. The latter, termed Cushing's disease , was recognized and described by Harvey Cushing in 1932. The syndrome is characterized by centripetal obesity, plethoric moon-shaped facies, hirsutism, acne, diabetes, hypertension, muscle weakness, bruising, mental disorders, amenorrhea and osteoporosis, all due to gluco-corticoid hypersecretion. Hyperpigmentation is associated with ectopic ACTH production and, in severe cases, with pituitary-dependent ACTH excess. This is because the pro-hormone from which ACTH is eventually cleaved (pro-opiomelanocortin) also contains the amino acid sequences for melanocyte-stimulating hormone. Left untreated, Cushing's disease leads to severe complications.


Minimize TSH stimulation, which promotes tumor growth. However, controversies remain regarding the level of thyrotropin suppression. It seems reasonable to adjust the level of TSH suppression based on the patient's initial clinicopatholo-gic features (103). Thyroid-stimulating hormone levels of 0.1 mU L or less are usually recommended to minimize the risk of tumor growth however, treatment with higher doses of thyroid hormone is associated with greater risk of osteoporosis, especially in postmenopausal women. In patients with an undetectable serum Tg concentration and negative neck ultrasound during follow-up, the risk of recurrence is so low that thyroxine doses which maintain TSH levels between 0.1 and 0.5 mU L are recommended.

Get Enough Calcium

Many people with MS are at risk for osteoporosis. If you are taking corticosteroids or are less mobile (using a wheelchair or confined to bed), you are more at risk for this condition that usually occurs later in life. Be sure to talk to your healthcare provider about having your bone density checked and taking prescription medicines for preventing or treating osteoporosis if necessary. You can decrease the risk by limiting alcohol intake, quitting smoking, doing weight-bearing exercise (like walking, dancing, or stair climbing), and taking in an adequate amount of calcium. Depending on your age, the recommended daily intake of calcium is between 1,000 and 1,300 mg per day, the amount in three to four 8-ounce glasses of low fat milk per day or the equivalent, so be sure to include milk, yogurt, and cheese often. If you are lactose intolerant, you can choose lactose-free dairy products or try Lactaid pills. Calcium-fortified soy milk is another alternative. If you don't like milk

Vitamin And Minerals

Some of the questions surrounding certain nutrient supplementation are particularly relevant to the management of the older patient with diabetes. These include vitamins for wound healing and bone health. Pressure sores develop in 4-10 of newly hospitalised patients, increasing to 14 in long-term elderly care (39). Patients with diabetes are a vulnerable group with poor wound healing. To date there is insufficient evidence to support the routine supplementation of micronutrients for wound or leg ulcer healing using either All elderly people are at risk of fractures due to falls and osteoporosis, but when diabetes is present this risk may be further increased by peripheral neuropathy, autonomic neuropathy, hypoglycaemic episodes and poor eyesight. In 1998 the Department of Health recommended the reference nutrient intake for calcium for people over 50 years of age to be 700 mg daily (43), with this being obtained from milk and milk-based foods. The National Osteoporosis Society (NOS)...


Vital for the proper function of all cells also essential for proper bone formation and maintenance. Supplementation not generally recommended, except to acutely support healing. Even in the presence of osteoporosis, calcium supplementation has strong counterbalancing negatives, promoting most other degenerative diseases, including cancer and heart disease.

Figure 1016

Quite often OM is identified rather late because it presents with vague nonspecific complaints that simulate other common conditions such as fibromyalgia, polymyalgia rheumatica, polymyositis, osteoporosis, and metastatic diseases. Cuenod CA, Laredo JD, Chevret S, Hamze B, Naouri JF, Chapeau X, Bondeville JM, Tubiana JM Acute vertebral collapse due to osteoporosis or malignancy Appearance on unenhanced and gadolinium-enhanced MR images. Radiology 199 541-549, 1996. Dublin AB, Hartman J, Latchaw RE, Hald JK, Reid MH The vertebral body fracture in osteoporosis Restoration of height using percutaneous vertebroplasty. Am J Neuroradiol 26 489-492, 2005.

Spinal Metastases

X-rays are the less sensitive diagnostic tool for spinal metastases detection. Vertebral bodies can loose upwards of 50 of their density before it becomes detectable in plain films. The vertebral bodies may appear heterogeneous or motley on plain films. This appearance is not specific and can be found in osteoporosis as well. The vertebral bodies' shape, texture, and cortices should be critically observed. Special attention should be paid to the posterior vertebral body wall. The presence of a lytic (darker) or blastic (whiter) vertebral body may give away the presence of metastases. In some patients with metastatic prostate cancer the vertebral bodies may seem completely white (Figures 11-1A and 11-1B). The pedicles should be critically inspected. They are

Multiple Myeloma

Multiple myeloma is a systemic malignant disease. It is the most common primary tumor of bone. In its initial stages, marrow infiltration with plasma cells and increased bone resorption result in radiological appearance identical to that seen in osteoporosis. The disease leads to anemia, increased sedimentation rate, hypercalcemia, accumulation of paraprotein in the serum, and Bence-Jones protein in the urine. The diagnosis can be confirmed by finding abnormal serum and urine electrophoresis. Bone marrow biopsy establishes the diagnosis by demonstrating abundance (over 10 ) of malignant plasma cells. MRI is the best screening test in multiple myeloma patients who appear to have normal plain films or diffuse osteoporosis. In the initial stages of the disease, however, up to 50 of patients with proven bone marrow infiltration may have a normal-looking MRI.

Imaging Studies

PD is often incidentally diagnosed in plain radiographs that were obtained for other reasons. The radiological hallmarks of PD include coarse trabeculae, thickened cortical bones, lytic areas (osteoporosis cir-cumscripta) interspersed with dense sclerotic bone, and bony deformities. In typical cases sclerosis may occur in the vertebral margins resulting in picture frame vertebrae (Figures 12-1A and 12-1B). Rarely, diffuse, intense sclerosis of the entire vertebral body results in an ivory vertebra, which frequently looks like metastatic disease (prostate, breast, lymphoma). After prolonged periods of bone resorption and bone formation the affected bones thicken, enlarge, and, at times, deform. The adjacent soft tissues, however, remain normal. Bone scan should be obtained in order to establish the distribution of the disease.


Certain foods contain plant estrogens that are helpful in balancing hormone levels in the body. Phytoestrogens are similar in structure to estrogen and can alleviate and prevent menopausal symptoms. Soybeans, for example, contain natural estrogens called isoflavones that help prevent osteoporosis, heart disease, and estrogen-related cancers such as breast cancer. In a study, soybeans and flaxseed were tested and found to increase estrogenic activity in postmenopausal women when they stopped eating the foods, estrogen cell activity also dropped. One cup of soybeans contains 300 mg isoflavones which equals the estrogenic effect in one Premarin (a synthetic hormone) tablet.

Surgical Technique

The osteotomy is performed 3-6 cm away from the nonunion site and preferably with an osteotome rather than a motorized saw, to avoid the risk of bone tissue necrosis. The osteotomy level is chosen according to certain considerations areas of dystrophic skin and areas with phlogosis or infection are to be avoided. Moreover, the osteotomy must be performed at a healthy bone level, and radiograms may help exclude areas involved in nonunion or those with osteoporosis, sclerosis, with a closed medullary canal, or previously affected by inflammation.


More than 24 million Americans are considered osteoporotic and approximately 500,000 to 700,000 people annually sustain a vertebral body compression fracture. Approximately 85 of these fractures are due to primary osteoporosis and the rest are from secondary osteoporosis and malignancies affecting the vertebral bodies. Furthermore, 25 of all postmenopausal women experience a vertebral body fracture, and out of those, 84 have pain that impacts negatively on the quality of their life (1).

Prevention Treatment

Prevention of osteoporotic compression fractures is the mainstay of treatment. Traditional preventative interventions are geared to decrease the progression of osteoporosis as a whole. These measures include periodic bone density determinations (i.e., a Dual Energy X-ray Absorptiometry scans), a regular exercise program, vitamin D and calcium supplementation, and hormonal (estrogen) replacement. Recently other medications have become available for clinical use including Salmon Calcitonin, Alendronate Sodium (Fosamax), a bisphosphonate that acts by decreasing osteoclastic activity, and Raloxifene Hydrochloride (Evista) known as a specific estrogen receptor modulator (SERM) . Clinical studies have shown as much as a 50 reduction in osteoporosis-related fractures including vertebral body compression fractures in postmenopausal women on these medications (5,6). Fosamax promotes bone formation and decreases resorption by preventing the differentiation of precursor stromal cells into...


Risk factors for osteoporosis include female gender, increasing age, family history, Caucasian or Asian race, estrogen deficient state, nulliparity, sedentarism, lifelong history of low calcium intake, smoking, excessive alcohol or caffeine consumption, and use of glucocorticoid drugs. Patients who have already sustained a fragility fracture have a markedly increased risk of sustaining further fractures.

Raloxifene Evista

Raloxifene is approved for the prevention of osteoporosis. When used at 60 mg per day, raloxifene demonstrates modest increases (1.5-2 in 24 months) in bone density. This increase in density is half of that seen in those patients receiving ERT. Raloxifene also results in a beneficial effect on the lipid profile similar to that seen with estrogen.

Ageing and lifespan

Contrary to this optimistic prediction, both in economically developed and developing countries, the numbers of the oldest old, defined as persons over 85 years of age, have already significantly increased and there is persuasive evidence that death rates may actually decelerate in those who survive to these advanced ages. (7) It should not be assumed that all persons in the oldest old category will necessarily be severely incapacitated, since an autopsy-based study conducted on individuals aged 85 years and over found no diagnosable fatal pathology in at least 30 per cent of cases, suggesting that in many individuals the ultimate causes of death are linked to normal physiological decrements associated with ageing.(8) However, experience has so far shown that any increase in the numbers of very old persons would be accompanied by disproportionately larger groups of individuals with major age-related pathologies, ranging from osteoporosis to Alzheimer's disease. (9)

Fact and Fantasy

We reported two decades ago that biomolecules and molecular assemblages such as membranes and proteins can be stabilized in the dry state in the presence of a sugar found at high concentrations in many anhydrobiotic organisms, trehalose.1 We also showed that trehalose was clearly superior to other sugars in this regard.2 This effect seemed so clear it quickly led to wide-spread, and often uncritical, use of the sugar for preservation and other purposes. In fact, an array of applications for trehalose have been reported, ranging from stabilization of vaccines and liposomes to hypothermic storage of human organs.3 Other workers showed that it might even be efficacious in treatment of dry eye syndrome or dry skin in humans.4'5 Trehalose is prominendy listed as an ingredient in cosmetics, apparendy because it is reputed to inhibit oxidation of certain fatty acids in vitro that might be related to body odor.6 Trehalose has been shown by several groups to suppress free radical damage,...


The bisphosphonate group of drugs is used for the management of disorders typified by enhanced bone resorption such as Paget's disease and osteoporosis. Alendronate, a drug that is indicated for the treatment of osteoporosis, has been associated with adverse oesophageal and gastric events. Case reports of oesophagitis, oesophageal ulcer and of oesophageal stricture have been reported (Maconi and Bianchi Porro, 1995 Abdelmalek and Douglas, 1996 Colina et al., 1997, de Groen et al., 1996 Liberman and Hirsch, 1996 Naylor and Davies, 1996 Rimmer and Rawls, 1996 Kelly and Taggart, 1997 Levine and Nelson, 1997). Pamidronate also has been associated with oesophagitis (Lufkin et al., 1994).

RANKL Blockade

Other signal transduction intermediates within the bone metabolism signaling pathways are being targeted by investigational therapies. One of these molecular targets is receptor activator of nuclear factor-kappaB ligand (RANKL), which drives osteoclast differentiation and activation (20). Denosumab (AMG 162) is a fully human anti-RANKL monoclonal antibody (33). This agent has primarily been investigated for the management of postmenopausal osteoporosis, in which it has been shown to increase bone mineral density and reduce bone turnover in women with low bone mineral density (34). In a 24-week study evaluating the efficacy and safety of denosumab in women with bone metastases from breast cancer (N 255), the efficacy of denosumab in reducing the risk of SREs was not significantly different from that of IV bisphosphonates (35). Further studies are warranted to assess the activity of denosumab alone or in combination with bisphosphonates for the treatment of bone metastases from breast...

Replacement Therapy

In the treatment of secondary adrenocortical insufficiency, lower doses of cortisol are generally effective, and fluid and electrolyte disturbances do not have to be considered, since patients with deficient corticotrophin secretion generally do not have abnormal function of the zona glomerulosa. Since cortisol replacement therapy is required for life, adequate assessment of patients is critical to avoid the serious long-term consequences of excessive or insufficient treatment. In many cases, the doses of glucocorticoid used in replacement therapy are probably too high. Patients should ideally be administered three or more doses daily. To limit the risk of osteoporosis, replacement therapy should be carefully assessed on an individual basis and overtreatment avoided.


The use of LMWSs, even if prolonged, is associated with a lower rate of plateletpenia and osteoporosis than the use of unfractionated heparin. These features are common to all LMWHs, although they differ in average molecular weight, specific anti-Xa and anti-IIa activity, and anti-Xa and anti-IIa rate.

Health needs

People with mental retardation need to have access to regular health screening.(35) In later life, women at risk of osteoporosis should be offered hormone replacement therapy. Pictorial health education materials are available to help health-care professionals provide information about illness, medical procedures, and treatment to people with limited verbal communication.*3.6)


Concomitant treatment with glucocorticoids can protect against the progression of opthalmopathy in patients with nonsevere ophthalmopathy (53,54). As worsening of pre-existing eye disease is more frequent than new ophtha-lmopathy following RAI treatment, patients most likely to benefit from corticos-teroids are those with clinically evident eye disease, especially if they continue smoking. Prednisone, 0.4-0.5 mg kg per day, beginning immediately after radioiodine treatment, continued for one month, and then tapered over three months, has been shown to be effective in a randomized controlled trial (53). As both hyperthyroidism and corticosteroids may increase bone turnover, patients receiving long-term corticosteroids should be considered for evaluation of bone density and therapies to prevent osteoporosis. Pretreatment with methi-mazole does not appear to prevent the development or exacerbation of ophthal-mopathy after RAI treatment (55). Patients with more severe ophthalmopathy...

Bone Metastases

Tl-weighted and fat suppressing STIR sequences are the most useful sequences for identifying lesions. T2*-weighted gradient echo images, though less sensitive than T1 and STIR sequences, may show lesions by their loss of susceptibility artifact, due to disruption of the trabeculae, and may help identify fractures and osteoblastic healing in osteoporosis. T2-weighted spin echo sequences are of limited use. Intravenous contrast may be helpful as the metastatic tumour will enhance, though this is not routinely used.

Epidural Lipomatosis

Crowding The Thecal Sac

Osteoporosis and compression fractures may be seen in patients on long-term steroids. The CT scan will demonstrate low attenuation mass typical for the excessive, epidur-ally deposited, fatty tissue. In cases with severe thecal sac compression axial cuts will show a dural sac deformation in stellar, trifid, or Y shapes. This has been coined the Y sign and can also be seen on axial cuts in MRI examination. It has been proposed that the Y shape found in severe cases of epidural lipomatosis is brought about by the presence of meningovertebral ligaments that anchor the outer surface of the dura mater to the osteofibrous walls of the lumbar spinal canal.

Malnutrition in ibd

Metabolic bone disease is commonly observed in those with inflammatory bowel disease. Clearly malnutrition contributes to this phenomenon. Hypocalcemia is seen in more than 10 of those with inflammatory bowel disease. This is often associated with decreased levels of vitamin D and in those patients on corticosteroid therapy. Osteopenia has been reported in more than half of patients with deficient 25-OH vitamin D levels (less than 25 nmol l). However, a recent study of 242 patients with Crohn's disease low bone mineral density (BMD) was not more frequent in those with the low 25-OH vitamin D levels, although parathyroid hormone and alkaline phosphatase were significantly higher in this group 35 . Decreased sunlight exposure, compromised nutritional status (as indicated by low levels of red blood cell folate and serum iron) and smoking were associated with lower levels of 25-OH vitamin D in this geographically localized population of northwestern Canadian patients with Crohn's disease....

M mMSSMM msm

Although the use of the injection sets increases the expense of the procedure, it is safer than free-hand injection. The injection of the cement has to be carefully controlled either under lateral and ap fluoroscopy or CT fluoroscopy to avoid cement leakage harming the patient. Special care has to be taken if the cement starts to leak out into the peridural space, since this can cause severe neurological deficits. The risk of cement leakage is particularly high at the beginning of cement injection. The operator should be very careful during the injection of the first amount of cement. The administration of the PMMA has to be stopped immediately if the mixture starts to leak out from the vertebral body into the surrounding tissue, especially into the discal space. However, waiting for 30-60 s can often resolve this problem because the cement hardens and seals the leak. If the leak persists, needle position and bevel direction should be changed. If cement...

Table 1424

Sheffield, M., Wolfe, R. et al., The effect of short term oxandrolone treatment on peripheral amino acid metabolism, J. Burn Care Rehab., 2, 127, 1999. Lafferty, F., Spencer, G., and Pearson, O., Effect of androgens, estrogens and high calcium intakes on bone formation and resorption in osteoporosis, Am. J. Med., 36, 514-528, 1969.


Those found in soy products, as a potential alternative to the synthetic estrogens in HRT (24,36,42,43). Together with lig-nans, coumestans, flavones, and flavanones, isoflavones belong to the larger group of nonsteroidal phytoestrogens. Interest in phytoestrogens has been fueled by observational studies showing a lower incidence of menopausal symptoms, osteoporosis, cardiovascular disease, and breast and endometrial cancers in Asian women who have a diet rich in soy products. Consistent with epidemiological studies are the findings that soy phy-toestrogens prevent mammary tumors and bone loss in rodents and atherosclerosis of coronary arteries in monkeys. Soy protein relieves hot flashes in postmenopausal women and attenuates bone loss in the lumbar spine of perimenopausal women. Furthermore, a high intake of dietary phytoestrogens is associated with a lower incidence of cancers of the colon, breast, and prostate. Isoflavones and other phytoestrogens have been considered to exert...


In the past decade, nutrition research has undergone an important shift in focus from epidemiology and physiology to molecular biology and genetics. This is a result of a growing realization that the effects of nutrition on health and disease cannot be understood without a profound understanding of how nutrients act at the molecular level micronutrients and macronutrients can be potent dietary signals that influence the metabolic programming of cells and have an important role in the control of homeostasis and or disease (28,240). Phytoestrogens are plant-derived molecules with estrogen-like action. Numerous reports exist on the potential beneficial role of nutritional phytoestrogens in human health (cancer chemoprevention, relief of postmenopausal symptoms, osteoporosis amelioration) (13-15,18-20). Herbal extracts are frequently used in traditional Chinese medicine for the treatment of hormonal disturbances or as health benefiting supplements (19). Often these preparations are...

Figure 102

Potts Disease Thoracic Spine Image

When osteoporosis or vertebral fractures are detected, systemic diseases such as hematological malignancies (multiple myeloma or metastatic disease) should be excluded. The work-up should include sedimentation rate, complete blood count, serum calcium, phosphorus, uric acid, serum and urine protein electrophoresis, and liver function tests. Osteoporosis work-up should also include blood levels of 25-hydroxyvitamin D, parathyroid hormone, osteocalcin (a bone formation marker), and 24-hour urine calcium excretion. Bone density studies using dual photon X-ray absorptiometry (DEXA) can confirm the presence of osteoporosis and quantify its severity. Plain films are not sensitive and remain normal in the early stages of osteoporosis. Up to 50-70 of bone loss can occur before osteoporosis is detectable on plain films. The main features of spinal osteoporosis are cortical bone thinning and resorption of bone trabeculae expressed on plain X-rays as decreased bone density. The bones appear more...


In humans, observational studies have noted an inverse relationship between dietary calcium intake, and specifically of dairy products intake, and body mass index or body fat,138 but these effects could be due to other characteristics of high-calcium dairy consumers. A systematic review of randomized trials of calcium dairy supplementation (which were designed to analyze end-points related to bone health, but included information on changes in body weight composition) concluded that the data available provide little support for an effect of calcium in reducing body weight or

White Adipose Tissue

Ppar Pathway White Adipose Tissue

Several decades ago it was recognised that adipose tissue could produce certain steroid hormones, including oestrogens (female sex hormones). This is because cells within adipose tissue (probably mainly cells other than the adipocytes) express the enzymes to interconvert steroid hormones. Oestrogens (such as oestradiol) can be produced from androgens (such as androstenedione) that are produced by the adrenal cortex (Section 5.5.1). This has important ramifications. In obesity, when there is an excess of adipose tissue, more oestrogens may be produced. That has some beneficial effects obese postmenopausal women (whose ovaries no longer produce oestrogens) are somewhat protected from osteoporosis, compared with lean women, because of this. The hormone cortisol is also produced from the inactive precursor cortisone. That may have untoward effects in obese men, adding to a metabolic 'stress' state.

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The Truth About Osteoporosis