S

Salicylic acid, plant stress response, 422 SAPK, see Stress-activated protein kinase SASA, see Solvent-accessible surface area SHM, see Stoichiometric hydration model

Shol, high osmolarity glycol signal transduction,

34, 41, 67 Skol, high osmolarity glycol signal transduction, 36 Slnl, high osmolarity glycol signal transduction,

34-35, 41, 67 Slt2, osmotic shock response, 31 SMIT, see Sodium/myo-inositol cotransporter Sodium/myo-inositol cotransporter, knockout mouse, 452 Solvation binding comparison, 460-461 Kirkwood-Buff analysis approximations, 464-467 dilute ligand specific binding, 482-483 elimination of parameters, 468 molal scale expressions, 467-468 molar scale expressions, 468-470 m value equation derivation, 474-476 interpretation, 476-479 osmolyte solvation equation derivation, 470-472 interpretation, 472-473 osmolyte specific binding explicitly taken into account, 480-481 solvation phenomenon, 479-480 solution and water structure, 461 thermodynamic derivation experimental data, 463-464 pair correlations, 462-463 Solvent-accessible surface area accuracy, 10

compact protein folding assumption, 8-9 equations, 5, 7

globular protein estimates based on stoichiometric hydration model, 9 SOS pathway, plant stress response, 426-427

Specific binding, see Kirkwood-Buffanalysis STATs, tonicity signaling, 280-281 Stoichiometric hydration model accuracy, 10-11

cellular function correlates, 24-25 compartmental capacity calculation, 3-5 enzyme function hydration and activity, 19-21 neutron scattering assessment of enzyme motion and activity, 21, 23 vibrational dynamics and activity change prediction, 23-24 hydration capacity prediction, 9, 11 osmosensing/osmosignaling relationship, 18-19

solvent-accessible surface area accuracy, 10

compact protein folding assumption, 8-9 equations, 5, 7

globular protein estimates based on stoichiometric hydration model, 9 water bridges, 3 Stress-activated protein kinase cell cycle control anaphase-telophase transition control,

71-72 G1 phase, 68-70 G2 phase, 70-71

mitotic exit network regulation, 82 prospects for study, 73-74 signaling cascade, 66-67 types in yeast, 67-68 Sty1, osmostress adaptation role, 68 Swelling assay, see Aquaporins, plants

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