G2

Mitosis

Figure 4-3 The osmocheckpoint modulates cell cycle transitions through SAPK activation. SAPKs from different yeasts act on several factors that control cell cycle progression positively (clear circles) or negatively (dark ellipses). Question marks indicate that the exact mechanism of action is not known. This figure suggests that SAPKs are able to protect cells from osmoinsults in any phase of the cell cycle.

Figure 4-3 The osmocheckpoint modulates cell cycle transitions through SAPK activation. SAPKs from different yeasts act on several factors that control cell cycle progression positively (clear circles) or negatively (dark ellipses). Question marks indicate that the exact mechanism of action is not known. This figure suggests that SAPKs are able to protect cells from osmoinsults in any phase of the cell cycle.

Again, the use of unicellular models has been shown to be very useful in uncovering complex responses. From yeast studies, we propose that a similar response to stress might be coordinated by SAPKs in mammals. Actually, different reports and unpublished observations indicate that different types ofmammalian cells arrest at several stages ofthe cell cycle upon osmostress (Gustin et al., 1998). Results from yeast suggest a conserved mechanism within more complex eukaryotic organisms.

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