This chapter summarizes the current approaches permitting the study of hyperosmolarity on membrane ruffling, Glut 4 translocation, glucose transport, and signaling pathways in 3T3-L1 adipocytes. It should be noted that hyperosmotic stress (usually induced by high extracellular concentrations of sorbitol) is not a physiological stimulus, but is used as a tool that could lead to the discovery of novel molecular mechanisms of glucose transport and also for a better understanding ofthe molecular mechanisms ofcellular insulin resistance.

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Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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