The TonE-binding protein (TonEBP) is a transcriptional activator in the Rel family that includes NFkB and NFAT. TonEBP is critical for the development and function of the renal medulla, which is a major regulator of water homeostasis. TonEBP is also implicated in diabetic nephropathy and inflammation. Established methods for biochemical and histochemical detection and functional

Department of Medicine, University of Maryland, Baltimore, Maryland

Methods in Enzymology, Volume 428 © 2007 Elsevier Inc.

ISSN 0076-6879, DOI: 10.1016/S0076-6879(07)28014-0 All rights reserved.

analysis of TonEBP, including identification of novel TonEBP target genes, are described for those who are interested in investigating function and regulation of TonEBP.

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